Treatment of Cytomegalovirus Retinitis With Cytomegalovirus-Specific T-Lymphocyte Infusion

被引：12

作者：

Gupta, Mrinali Patel ^{[1
]}

Coombs, Peter ^{[1
]}

Prockop, Susan E. ^{[2
]}

Hasan, Aisha A. ^{[2
]}

Doubrovina, Ekatarina ^{[2
]}

O'Reilly, Richard J. ^{[2
]}

Cohen, Stuart H. ^{[3
]}

Park, Susanna S. ^{[4
]}

Kiss, Szilard ^{[1
]}

机构：

[1] Weill Cornell Med Coll, Dept Ophthalmol, New York, NY 10021 USA

[2] Mem Sloan Kettering Canc Ctr, Dept Pediat, New York, NY 10021 USA

[3] Univ Calif Davis, Med Ctr, Dept Internal Med, Div Infect Dis, Sacramento, CA 95817 USA

[4] Univ Calif Davis, Ctr Eye, Dept Ophthalmol & Vis Sci, Sacramento, CA 95817 USA

来源：

OPHTHALMIC SURGERY LASERS & IMAGING RETINA | 2015年 / 46卷 / 01期

关键词：

CELLS;

D O I：

10.3928/23258160-20150101-14

中图分类号：

R77 [眼科学];

学科分类号：

100212 ;

摘要：

Cytomegalovirus (CMV) retinitis is a potentially blinding infection that affects immunocompromised patients who are unable to generate a T-cell response against the organism. Infusion of CMV-specific leukocytes has been shown to be effective in patients with systemic CMV infection, especially those resistant to standard therapies. The authors report a case of a patient with CMV viremia with progressive retinitis in whom infusion of third-party donor-derived CMV pp65-specific T cells alone prompted resolution of CMV retinitis. This case suggests a potential role for CMV-specific leukocyte infusion in the treatment of CMV retinitis, especially in cases resistant or refractory to antiviral therapies.

引用

页码：80 / 82

页数：3

共 7 条

[1]

Bodaghi B, 1999, INVEST OPHTH VIS SCI, V40, P2598

[2] Cytomegalovirus and the eye [J].

Carmichael, A. .

EYE, 2012, 26 (02) :237-240

[3] Infusion of cytomegalovirus (CMV)-specific T cells for the treatment of CMV infection not responding to antiviral chemotherapy [J].

Einsele, H ;

Roosnek, E ;

Rufer, N ;

Sinzger, C ;

Riegler, S ;

Löffler, J ;

Grigoleit, U ;

Moris, A ;

Rammensee, HG ;

Kanz, L ;

Kleihauer, A ;

Frank, F ;

Jahn, G ;

Hebart, H .

BLOOD, 2002, 99 (11) :3916-3922

[4] Adoptive transfer of pp65-specific T cells for the treatment of chemorefractory cytomegalovirus disease or reactivation after haploidentical and matched unrelated stem cell transplantation [J].

Feuchtinger, Tobias ;

Opherk, Kathrin ;

Bethge, Wolfgang A. ;

Topp, Max S. ;

Schuster, Friedhelm R. ;

Weissinger, Eva M. ;

Mohty, Mohamad ;

Or, Reuven ;

Maschan, Michael ;

Schumm, Michael ;

Hamprecht, Klaus ;

Handgretinger, Rupert ;

Lang, Peter ;

Einsele, Hermann .

BLOOD, 2010, 116 (20) :4360-4367

[5] A case of immune recovery vitritis induced by donor leukocyte infusion for the treatment of cytomegalovirus retinitis [J].

Kawakami, M ;

Nakata, J ;

Ohguro, N ;

Yoshihara, S ;

Inoue, T ;

Tatekawa, T ;

Ikegame, K ;

Oka, Y ;

Kawase, I ;

Ogawa, H .

EUROPEAN JOURNAL OF HAEMATOLOGY, 2005, 75 (04) :352-354

[6] Generation of CMV-specific T lymphocytes using protein-spanning pools of pp65-derived overlapping pentadecapeptides for adoptive immunotherapy [J].

Trivedi, D ;

Williams, RY ;

O'Reilly, RJ ;

Koehne, G .

BLOOD, 2005, 105 (07) :2793-2801

[7]

Vadalpudi AD, 2012, RECENT PAT ANTIINFEC, V7, P8

← 1 →