Dupilumab in the treatment of chronic rhinosinusitis with nasal polyposis

被引：23

作者：

Boyle, John V. ^{[1
]}

Lam, Kent K. ^{[1
]}

Han, Joseph K. ^{[1
]}

机构：

[1] Eastern Virginia Med Sch, Dept Otolaryngol Head & Neck Surg, Norfolk, VA 23507 USA

来源：

IMMUNOTHERAPY | 2020年 / 12卷 / 02期

关键词：

atopic; biologic; chronic rhinosinusitis; dupilumab; IL-4; IL-13; monoclonal antibodies; nasal polyps; polyposis; ENDOSCOPIC SINUS SURGERY; DOUBLE-BLIND; LEBRIKIZUMAB; PHASE-3;

D O I：

10.2217/imt-2019-0191

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Chronic rhinosinusitis with nasal polyposis (CRSwNP) imparts a significant healthcare challenge, resulting in diminished quality of life for patients and high costs with resource utilization for disease management. Understanding of CRSwNP pathophysiology has progressively evolved and the identification of various inflammatory biomarkers has led to the development of monoclonal antibodies that target the underlying mechanisms of inflammation. Dupilumab, which targets IL-4 and IL-13 signaling, serves as a novel agent for CRSwNP treatment. Three clinical trials, NCT01920893, SINUS-24 and SINUS-52, have shown that dupilumab improves both subjective patient-reported outcomes and objective physician-evaluated metrics for CRSwNP. The favorable findings have resulted in approval by the US FDA in June 2019 as the first biologic therapy for CRSwNP.

引用

页码：111 / 121

页数：11

共 40 条

[1] Conjunctivitis in dupilumab clinical trials [J].

Akinlade, B. ;

Guttman-Yassky, E. ;

de Bruin-Weller, M. ;

Simpson, E. L. ;

Blauvelt, A. ;

Cork, M. J. ;

Prens, E. ;

Asbell, P. ;

Akpek, E. ;

Corren, J. ;

Bachert, C. ;

Hirano, I. ;

Weyne, J. ;

Korotzer, A. ;

Chen, Z. ;

Hultsch, T. ;

Zhu, X. ;

Davis, J. D. ;

Mannent, L. ;

Hamilton, J. D. ;

Teper, A. ;

Staudinger, H. ;

Rizova, E. ;

Pirozzi, G. ;

Graham, N. M. H. ;

Shumel, B. ;

Ardeleanu, M. ;

Wollenberg, A. .

BRITISH JOURNAL OF DERMATOLOGY, 2019, 181 (03) :459-473

[2] Efficacy and safety of dupilumab in patients with severe chronic rhinosinusitis with nasal polyps (LIBERTY NP SINUS-24 and LIBERTY NP SINUS-52): results from two multicentre, randomised, double-blind, placebo-controlled, parallel-group phase 3 trials [J].

Bachert, Claus ;

Han, Joseph K. ;

Desrosiers, Martin ;

Hellings, Peter W. ;

Amin, Nikhil ;

Lee, Stella E. ;

Mullol, Joaquim ;

Greos, Leon S. ;

Bosso, John V. ;

Laidlaw, Tanya M. ;

Cervin, Anders U. ;

Maspero, Jorge F. ;

Hopkins, Claire ;

Olze, Heidi ;

Canonica, G. Walter ;

Paggiaro, Pierluigi ;

Cho, Seong H. ;

Fokkens, Wytske J. ;

Fujieda, Shigeharu ;

Zhang, Mei ;

Lu, Xin ;

Fan, Chunpeng ;

Draikiwicz, Steven ;

Kamat, Siddhesh A. ;

Khan, Asif ;

Pirozzi, Gianluca ;

Patel, Naimish ;

Graham, Neil M. H. ;

Ruddy, Marcella ;

Staudinger, Heribert ;

Weinreich, David ;

Stahl, Neil ;

Yancopoulos, George D. ;

Mannent, Leda P. .

LANCET, 2019, 394 (10209) :1638-1650

[3] Effect of Subcutaneous Dupilumab on Nasal Polyp Burden in Patients With Chronic Sinusitis and Nasal Polyposis A Randomized Clinical Trial [J].

Bachert, Claus ;

Mannent, Leda ;

Naclerio, Robert M. ;

Mullol, Joaquim ;

Ferguson, Berrylin J. ;

Gevaert, Philippe ;

Hellings, Peter ;

Jiao, Lixia ;

Wang, Lin ;

Evans, Robert R. ;

Pirozzi, Gianluca ;

Graham, Neil M. ;

Swanson, Brian ;

Hamilton, Jennifer D. ;

Radin, Allen ;

Gandhi, Namita A. ;

Stahl, Neil ;

Yancopoulos, George D. ;

Sutherland, E. Rand .

JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION, 2016, 315 (05) :469-479

[4]

Blackwell DL, 2018, TABLES SUMMARY HLTH

[5] Lebrikizumab Treatment in Adults with Asthma [J].

Corren, Jonathan ;

Lemanske, Robert F., Jr. ;

Hanania, Nicola A. ;

Korenblat, Phillip E. ;

Parsey, Merdad V. ;

Arron, Joseph R. ;

Harris, Jeffrey M. ;

Scheerens, Heleen ;

Wu, Lawren C. ;

Su, Zheng ;

Mosesova, Sofia ;

Eisner, Mark D. ;

Bohen, Sean P. ;

Matthews, John G. .

NEW ENGLAND JOURNAL OF MEDICINE, 2011, 365 (12) :1088-1098

[6] Prevalence of Polyp Recurrence After Endoscopic Sinus Surgery for Chronic Rhinosinusitis With Nasal Polyposis [J].

DeConde, Adam S. ;

Mace, Jess C. ;

Levy, Joshua M. ;

Rudmik, Luke ;

Alt, Jeremiah A. ;

Smith, Timothy L. .

LARYNGOSCOPE, 2017, 127 (03) :550-555

[7] How often is sinus surgery performed for chronic rhinosinusitis with versus without nasal polyps? [J].

Ference, Elisabeth H. ;

Suh, Jeffrey D. ;

Tan, Bruce K. ;

Smith, Stephanie Shintani .

AMERICAN JOURNAL OF RHINOLOGY & ALLERGY, 2018, 32 (01) :34-39

[8]

Fokkens WJ, 2012, RHINOLOGY, V50, P1

[9] EUFOREA consensus on biologics for CRSwNP with or without asthma [J].

Fokkens, Wytske J. ;

Lund, Valerie ;

Bachert, Claus ;

Mullol, Joaquim ;

Bjermer, Leif ;

Bousquet, Jean ;

Canonica, Giorgio W. ;

Deneyer, Lauren ;

Desrosiers, Martin ;

Diamant, Zuzana ;

Han, Joseph ;

Heffler, Enrico ;

Hopkins, Claire ;

Jankowski, Roger ;

Joos, Guy ;

Knill, Andrew ;

Lee, Jivianne ;

Lee, Stella E. ;

Marien, Gert ;

Pugin, Benoit ;

Senior, Brent ;

Seys, Sven F. ;

Hellings, Peter W. .

ALLERGY, 2019, 74 (12) :2312-2319

[10] Nasal IL-5 levels determine the response to anti-IL-5 treatment in patients with nasal polyps [J].

Gevaert, Philippe ;

Lang-Loidolt, Doris ;

Lackner, Andreas ;

Stammberger, Heinz ;

Staudinger, Heribert ;

Van Zele, Thibaut ;

Holtappels, Gabriele ;

Tavernier, Jan ;

van Cauwenberge, Paul ;

Bachert, Claus .

JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY, 2006, 118 (05) :1133-1141

← 1 2 3 4 →