C-reactive protein is superior to fecal biomarkers for evaluating colon-wide active inflammation in ulcerative colitis

被引：27

作者：

Ishida, Natsuki ^{[1
]}

Higuchi, Tomohiro ^{[1
]}

Miyazu, Takahiro ^{[1
]}

Tamura, Satoshi ^{[1
]}

Tani, Shinya ^{[1
]}

Yamade, Mihoko ^{[1
]}

Iwaizumi, Moriya ^{[2
]}

Hamaya, Yasushi ^{[1
]}

Osawa, Satoshi ^{[3
]}

Furuta, Takahisa ^{[4
]}

Sugimoto, Ken ^{[1
]}

机构：

[1] Hamamatsu Univ Sch Med, Dept Med 1, Hamamatsu, Shizuoka, Japan

[2] Hamamatsu Univ Sch Med, Dept Lab Med, Higashi Ku, I-20-1 Handayama, Hamamatsu, Shizuoka 4313192, Japan

[3] Hamamatsu Univ Sch Med, Dept Endoscop & Photodynam Med, Hamamatsu, Shizuoka, Japan

[4] Hamamatsu Univ Sch Med, Clin Res Ctr, Hamamatsu, Shizuoka, Japan

来源：

SCIENTIFIC REPORTS | 2021年 / 11卷 / 01期

关键词：

BOWEL-DISEASE; ENDOSCOPIC ACTIVITY; IMMUNOCHEMICAL TEST; BLOOD BIOMARKERS; CALPROTECTIN; SEVERITY; INDEX; HEMOGLOBIN; THERAPY; MARKERS;

D O I：

10.1038/s41598-021-90558-z

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

We evaluated the association between endoscopic scores of colonic inflammation and fecal calprotectin (FC), fecal immunochemical occult blood test (FIT), and C-reactive protein (CRP) in patients with ulcerative colitis (UC). Endoscopic scores reflecting the most severe lesion [maximum Mayo Endoscopic Subscore (M-MES) and Ulcerative Colitis Endoscopic Index of Severity (UCEIS)] and those reflecting the inflammation of the entire colon [sum of MES (S-MES) and Ulcerative Colitis Colonoscopic Index of Severity (UCCIS)] were evaluated. FC, FIT, and CRP were measured, and their association with the four endoscopic scores was evaluated. Endoscopic scores of 78 complete colonoscopies (66 UC patients) were evaluated using the three biomarkers. FC and CRP tended to correlate more strongly with S-MES and UCCIS than with M-MES and UCEIS. In the M-MES 0, 1 group, compared to CRP, FC and FIT showed stronger correlations with S-MES and UCCIS. Conversely, in the M-MES 2, 3 group, only CRP was significantly correlated with each descriptor. CRP more strongly reflects colon-wide mucosal inflammation than FC and allows reliable assessment of inflammation throughout the colon in active UC.

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页数：8

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