Fluoxetine treatment of children with selective mutism: An open trial

被引：101

作者：

Dummit, SE ^{[1
]}

Klein, RG ^{[1
]}

Tancer, NK ^{[1
]}

Asche, B ^{[1
]}

Martin, J ^{[1
]}

机构：

[1] COLUMBIA UNIV, COLL PHYS & SURG, NEW YORK STATE PSYCHIAT INST, NEW YORK, NY USA

来源：

JOURNAL OF THE AMERICAN ACADEMY OF CHILD AND ADOLESCENT PSYCHIATRY | 1996年 / 35卷 / 05期

关键词：

elective mutism; selective mutism; anxiety; social phobia; avoidant disorder; child; adolescent; fluoxetine;

D O I：

10.1097/00004583-199605000-00016

中图分类号：

B844 [发展心理学（人类心理学）];

学科分类号：

040202 ;

摘要：

Objective: A pilot study was designed to evaluate the safety and efficacy of fluoxetine treatment for children with selective mutism (elective mutism in DSM-III-R). Method: Twenty-one children (mean age 8.2 years, range 5 through 14) participated in a 9-week open trial of fluoxetine in graduated doses (mean end dose 28.1 mg, range 10 to 60 mg) with systematic baseline and outcome evaluations and weekly clinical assessment. Results: All 21 children met DSM-III-R and DSM-IV criteria for anxiety disorders. After fluoxetine treatment, 76% were improved, with diminished anxiety and increased speech in public settings, including school. Improvement at week 9 was inversely correlated with age. Conclusions: Persistent selective mutism presenting with comorbid anxiety disorders may respond to fluoxetine treatment.

引用

页码：615 / 621

页数：7

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