Synthesis and antibacterial activities of new biphenyltetrazole derivatives bearing 1,2,4-triazole

S-Alkylation products were synthesized by the reaction of 4-aryl-5-(4-pridyl)-1,2,4-triazole-3thiol (1) with 2-trityl-5-(4'-bromomethylbiphen-2-yl)tetrazole (5). An attempt to remove the trityl group of S-alkylation products 6 under acidic conditions gave fourteen new triazole ring containing biphenyl tetrazoles 7a similar to 7n in good yields. The structures of these compounds synthesized were confirmed by elemental analyses, IR, NMR and FAB-MS. Primary antibacterial test against E. coli, Streptococcus, B. subtilis and S. aureus showed that most of them had good antibacterial activities.