The antitumor effect of folic acid conjugated-Auricularia auricular polysaccharide-cisplatin complex on cervical carcinoma cells in nude mice

被引：33

作者：

Qiu, Junqiang ^{[1
]}

Zhang, Hua ^{[1
]}

Wang, Zhenyu ^{[1
]}

Liu, Didi ^{[1
]}

Liu, Shumin ^{[2
]}

Han, Wei ^{[2
]}

Regenstein, Joe M. ^{[3
]}

Geng, Lin ^{[4
]}

机构：

[1] Harbin Inst Technol, Sch Chem & Chem Engn, Dept Food Sci, Harbin, Heilongjiang, Peoples R China

[2] Heilongiang Univ Chinese Med, Minist Educ & Prov Dept, Joint Constructed Key Lab Northern Drug Res & App, Harbin, Heilongjiang, Peoples R China

[3] Cornell Univ, Dept Food Sci, Ithaca, NY 14853 USA

[4] Harbin Inst Technol, Sch Mat Sci & Engn, Harbin, Heilongjiang, Peoples R China

来源：

INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES | 2018年 / 107卷

基金：

中国国家自然科学基金;

关键词：

Cisplatin; Folic acid; Nude mice; Tumor cells; Folate receptors; IN-VIVO; DELIVERY-SYSTEM; DRUG-DELIVERY; INDUCED NEPHROTOXICITY; ANTIOXIDANT ACTIVITY; TARGETED DELIVERY; CANCER-THERAPY; CHITOSAN NANOPARTICLES; GRAPHENE OXIDE; SEM-EDS;

D O I：

10.1016/j.ijbiomac.2017.10.087

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

A tumor-targeted, folic acid (FA) conjugated-Auricularia auricular polysaccharide (AAP) -cis-diaminedichloroplatinum (CDDP) complex (FA-AAP-CDDP) was used for cervical carcinoma chemotherapy. The drug delivery system was able to enhance the antitumor potency of CDDP, and to reduce the toxic side effects of CDDP. The kidney of mice treated by FA-AAP-CDDP complex had higher superoxide dismutase, catalase, and glutathione peroxidase activities, and lower malondialdehyde. FA-AAP-CDDP complex could induce more interleukin-2, interleukin-4, and interferon-gamma in mice. In addition, the FA-AAP-CDDP complex significantly promoted the expression of Bax and caspase-3 protein, but inhibited the expression of Bcl-2 protein, which activated the mitochondrial apoptotic pathway of tumor cells in nude mice. Moreover, the FA-AAP-CDDP complex had a higher intratumoral accumulation, was lower in the kidneys. This study may provide a new direction for folate receptor targeted polymers to improve anti-tumor activity, but reduce side effects of CDDP. (C) 2017 Published by Elsevier B.V.

引用

页码：2180 / 2189

页数：10

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