Stress, depression and Parkinson's disease

被引：154
作者：
Hemmerle, Ann M. [2 ]
Herman, James P. [2 ,3 ]
Seroogy, Kim B. [1 ,2 ]
机构：
[1] Univ Cincinnati, Coll Med, Dept Neurol, James J & Joan A Gardner Family Ctr Parkinsons Di, Cincinnati, OH 45267 USA
[2] Univ Cincinnati, Grad Program Neurosci, Cincinnati, OH 45267 USA
[3] Univ Cincinnati, Coll Med, Dept Psychiat & Behav Neurosci, Cincinnati, OH 45267 USA
来源：
EXPERIMENTAL NEUROLOGY | 2012年 / 233卷 / 01期
关键词：
Glucocorticoids; Chronic variable stress; HPA axis; Dopamine; Neurodegeneration; Non-motor symptoms; CHRONIC MILD STRESS; HIPPOCAMPAL CA3C NEURONS; MEDIAL PREFRONTAL CORTEX; QUALITY-OF-LIFE; GLUCOCORTICOID-RECEPTOR; MESSENGER-RNA; MAJOR DEPRESSION; LOCUS-COERULEUS; RAT MODEL; DENDRITIC REORGANIZATION;
D O I：
10.1016/j.expneurol.2011.09.035
中图分类号：
Q189 [神经科学];
学科分类号：
071006 ;
摘要：
In this review, we focus on the relationship among Parkinson's disease (PD), stress and depression. Parkinson's disease patients have a high risk of developing depression, and it is possible that stress contributes to the development of both pathologies. Stress dysfunction may have a role in the etiology of preclinical non-motor symptoms of PD (such as depression) and, later in the course of the disease, may worsen motor symptoms. However, relatively few studies have examined stress or depression and the injured nigrostriatal system. This review discusses the effects of stress on neurodegeneration and depression, and their association with the symptoms and progression of PD. (C) 2011 Elsevier Inc. All rights reserved.
引用
收藏
页码：79 / 86
页数：8
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