Stimuli-Responsive Peptide-Based ABA-Triblock Copolymers: Unique Morphology Transitions With pH

被引：42

作者：

Ray, Jacob G. ^{[1
]}

Naik, Sandeep S. ^{[1
]}

Hoff, Emily A. ^{[1
]}

Johnson, Ashley J. ^{[1
]}

Ly, Jack T. ^{[1
]}

Easterling, Charles P. ^{[1
]}

Patton, Derek L. ^{[1
]}

Savin, Daniel A. ^{[1
]}

机构：

[1] Univ So Mississippi, Sch Polymers & High Performance Mat, Hattiesburg, MS 39406 USA

来源：

MACROMOLECULAR RAPID COMMUNICATIONS | 2012年 / 33卷 / 09期

基金：

美国国家科学基金会;

关键词：

disk micelle; light scattering; morphology; polypeptide; spherical micelle; vesicle; AMPHIPHILIC BLOCK-COPOLYMERS; DIBLOCK COPOLYMERS; AQUEOUS-SOLUTIONS; SECONDARY STRUCTURE; DRUG-DELIVERY; MICELLES; VESICLES; WATER; SURFACTANTS; POLYMERS;

D O I：

10.1002/marc.201100881

中图分类号：

O63 [高分子化学（高聚物）];

学科分类号：

070305 ; 080501 ; 081704 ;

摘要：

We report the synthesis and solution characterization of poly(L-lysine)-b-poly(propylene oxide)-b-poly(L-lysine) (KPK) triblock copolymers with high lysine weight fractions (>75 wt%). In contrast to PK diblock copolymers in this composition range, KPK triblock copolymers exhibit morphology transitions as a function of pH. Using a combination of light-scattering and microscopy techniques, we demonstrate spherical micelle-vesicle and spherical micelle-disk micelle transitions for different K fractions. We interpret these morphology changes in terms of the energy penalty associated with folding the core P block to form a spherical micelle in relation to the interfacial curvature associated with different charged states of the K block.

引用

页码：819 / 826

页数：8

共 48 条

[11] 2-G
[12] Polymer vesicles
Discher, DE
Eisenberg, A
[J]. SCIENCE, 2002, 297 (5583) : 967 - 973
[13] Disk micelles from nonionic coil-coil diblock copolymers
Edmonds, William F.
Li, Zhibo
Hillmyer, Marc A.
Lodge, Timothy P.
[J]. MACROMOLECULES, 2006, 39 (13) : 4526 - 4530
[14] From self-organizing polymers to nano- and biomaterials
Förster, S
Konrad, M
[J]. JOURNAL OF MATERIALS CHEMISTRY, 2003, 13 (11) : 2671 - 2688
[15] Forster S, 1998, ADV MATER, V10, P195, DOI 10.1002/(SICI)1521-4095(199802)10:3<195::AID-ADMA195>3.0.CO
[16] 2-V
[17] Role of secondary structure changes on the morphology of polypeptide-based block copolymer vesicles
Gebhardt, Kay E.
Ahn, Sungsook
Venkatachalam, Gopal
Savin, Daniel A.
[J]. JOURNAL OF COLLOID AND INTERFACE SCIENCE, 2008, 317 (01) : 70 - 76
[18] Rod-sphere transition in polybutadiene-poly(L-lysine) block copolymer assemblies
Gebhardt, Kay E.
Ahn, Sungsook
Venkatachalam, Gopal
Savin, Daniel A.
[J]. LANGMUIR, 2007, 23 (05) : 2851 - 2856
[19] Properties of pH-Responsive Mixed Aggregates of Polystyrene-block-poly(L-lysine) and Nonionic Surfactant in Solution and Adsorbed at a Solid Surface
Gil, Guillermo Orts
Losik, Magdalena
Schlaad, Helmut
Drechsler, Markus
Hellweg, Thomas
[J]. LANGMUIR, 2008, 24 (22) : 12823 - 12828
[20] Block copolymer micelles
Gohy, JF
[J]. BLOCK COPOLYMERS II, 2005, 190 : 65 - 136

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