Stimuli-Responsive Peptide-Based ABA-Triblock Copolymers: Unique Morphology Transitions With pH

被引：42

作者：

Ray, Jacob G. ^{[1
]}

Naik, Sandeep S. ^{[1
]}

Hoff, Emily A. ^{[1
]}

Johnson, Ashley J. ^{[1
]}

Ly, Jack T. ^{[1
]}

Easterling, Charles P. ^{[1
]}

Patton, Derek L. ^{[1
]}

Savin, Daniel A. ^{[1
]}

机构：

[1] Univ So Mississippi, Sch Polymers & High Performance Mat, Hattiesburg, MS 39406 USA

来源：

MACROMOLECULAR RAPID COMMUNICATIONS | 2012年 / 33卷 / 09期

基金：

美国国家科学基金会;

关键词：

disk micelle; light scattering; morphology; polypeptide; spherical micelle; vesicle; AMPHIPHILIC BLOCK-COPOLYMERS; DIBLOCK COPOLYMERS; AQUEOUS-SOLUTIONS; SECONDARY STRUCTURE; DRUG-DELIVERY; MICELLES; VESICLES; WATER; SURFACTANTS; POLYMERS;

D O I：

10.1002/marc.201100881

中图分类号：

O63 [高分子化学（高聚物）];

学科分类号：

070305 ; 080501 ; 081704 ;

摘要：

We report the synthesis and solution characterization of poly(L-lysine)-b-poly(propylene oxide)-b-poly(L-lysine) (KPK) triblock copolymers with high lysine weight fractions (>75 wt%). In contrast to PK diblock copolymers in this composition range, KPK triblock copolymers exhibit morphology transitions as a function of pH. Using a combination of light-scattering and microscopy techniques, we demonstrate spherical micelle-vesicle and spherical micelle-disk micelle transitions for different K fractions. We interpret these morphology changes in terms of the energy penalty associated with folding the core P block to form a spherical micelle in relation to the interfacial curvature associated with different charged states of the K block.

引用

页码：819 / 826

页数：8

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