The Gastrointestinal Pharmacology of Cannabinoids: Focus on Motility

被引：49

作者：

Abalo, Raquel ^{[1
]}

Vera, Gema ^{[1
]}

Lopez-Perez, Ana Esther ^{[2
]}

Martinez-Villaluenga, Maria ^{[1
]}

Martin-Fontelles, Maria Isabel ^{[1
]}

机构：

[1] Univ Rey Juan Carlos, Fac Ciencias Salud, Dept Farmacol & Nutr, ES-28922 Alcorcon, Spain

[2] Hosp Gen Univ Gregorio Maranon, Serv Anestesia, Unidad Dolor, Madrid, Spain

来源：

PHARMACOLOGY | 2012年 / 90卷 / 1-2期

关键词：

Cannabinoid; Gut; Gastrointestinal motility; Ileus; Irritable bowel disease; Gastro-oesophageal reflux; Nausea; Emesis; CHEMOTHERAPY-INDUCED NAUSEA; ENDOCANNABINOID SYSTEM; GUINEA-PIG; INHIBIT EMESIS; CB1; RECEPTORS; WIN 55,212-2; BRAIN-STEM; CANNABIDIOL; ANANDAMIDE; COLITIS;

D O I：

10.1159/000339072

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

The marijuana plant Cannabis sp. and its derivatives and analogues, known as cannabinoids (CBs), induce many effects throughout the whole body. Herein we briefly review the gastrointestinal (GO pharmacology of CBs, with special focus on motor function. Some drugs are available to treat nausea and emesis, and evidences in humans and animal models suggest that other GI motility alterations (gastro-oesophageal reflux, inflammatory bowel conditions or paralytic ileus) might benefit from modifications of the CB tone throughout the gut. However, central and peripheral (including GI) side effects may occur upon acute and chronic CB administration. Hopefully, the ongoing worldwide intense research on CBs will soon provide new, safer CB-based medicines. Copyright (C) 2012 S. Karger AG, Basel

引用

页码：1 / 10

页数：10

共 78 条

[1] Cannabinoid-induced delayed gastric emptying is selectively increased upon intermittent administration in the rat: role of CB1 receptors [J].

Abalo, R. ;

Cabezos, P. A. ;

Vera, G. ;

Lopez-Miranda, V. ;

Herradon, E. ;

Martin-Fontelles, M. I. .

NEUROGASTROENTEROLOGY AND MOTILITY, 2011, 23 (05) :457-e177

[2] The cannabinoid antagonist SR144528 enhances the acute effect of WIN 55,212-2 on gastrointestinal motility in the rat [J].

Abalo, R. ;

Cabezos, P. A. ;

Vera, G. ;

Fernandez-Pujol, R. ;

Martin, M. I. .

NEUROGASTROENTEROLOGY AND MOTILITY, 2010, 22 (06) :694-+

[3] Selective lack of tolerance to delayed gastric emptying after daily administration of WIN 55,212-2 in the rat [J].

Abalo, R. ;

Cabezos, P. A. ;

Lopez-Miranda, V. ;

Vera, G. ;

Gonzalez, C. ;

Castillo, M. ;

Fernandez-Pujol, R. ;

Martin, M. I. .

NEUROGASTROENTEROLOGY AND MOTILITY, 2009, 21 (09) :1002-e80

[4] Increasing endogenous 2-arachidonoylglycerol levels counteracts colitis and related systemic inflammation [J].

Alhouayek, Mireille ;

Lambert, Didier M. ;

Delzenne, Nathalie M. ;

Cani, Patrice D. ;

Muccioli, Giulio G. .

FASEB JOURNAL, 2011, 25 (08) :2711-2721

[5] Cannabinoid hyperemesis: cyclical hyperemesis in association with chronic cannabis abuse [J].

Allen, JH ;

de Moore, GM ;

Heddle, R ;

Twartz, JC .

GUT, 2004, 53 (11) :1566-1570

[6] Signals for nausea and emesis: Implications for models of upper gastrointestinal diseases [J].

Andrews, Paul L. R. ;

Horn, Charles C. .

AUTONOMIC NEUROSCIENCE-BASIC & CLINICAL, 2006, 125 (1-2) :100-115

[7] Radiological study of gastrointestinal motor activity after acute cisplatin in the rat.: Temporal relationship with pica [J].

Antonio Cabezos, Pablo ;

Vera, Gema ;

Castillo, Monica ;

Fernandez-Pujol, Ramon ;

Isabel Martin, Maria ;

Abalo, Raquel .

AUTONOMIC NEUROSCIENCE-BASIC & CLINICAL, 2008, 141 (1-2) :54-65

[8]

Aviello G, 2008, EUR REV MED PHARMACO, V12, P81

[9] Inhibiting fatty acid amide hydrolase normalizes endotoxin-induced enhanced gastrointestinal motility in mice [J].

Bashashati, M. ;

Storr, M. A. ;

Nikas, S. P. ;

Wood, J. T. ;

Godlewski, G. ;

Liu, J. ;

Ho, W. ;

Keenan, C. M. ;

Zhang, H. ;

Alapafuja, S. O. ;

Cravatt, B. F. ;

Lutz, B. ;

Mackie, K. ;

Kunos, G. ;

Patel, K. D. ;

Makriyannis, A. ;

Davison, J. S. ;

Sharkey, K. A. .

BRITISH JOURNAL OF PHARMACOLOGY, 2012, 165 (05) :1556-1571

[10] Effect of Δ9-tetrahydrocannabinol, a cannabinoid receptor agonist, on the triggering of transient lower oesophageal sphincter relaxations in dogs and humans [J].

Beaumont, H. ;

Jensen, J. ;

Carlsson, A. ;

Ruth, M. ;

Lehmann, A. ;

Boeckxstaens, G. E. .

BRITISH JOURNAL OF PHARMACOLOGY, 2009, 156 (01) :153-162

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