The synthesis of novel 3′,5′-homocyclic nucleotides as potential anti-HIV agents

被引：7

作者：

Drew, MGB ^{[1
]}

Gorsuch, S ^{[1
]}

Gould, JHM ^{[1
]}

Mann, J ^{[1
]}

机构：

[1] Univ Reading, Dept Chem, Reading RG6 6AD, Berks, England

来源：

JOURNAL OF THE CHEMICAL SOCIETY-PERKIN TRANSACTIONS 1 | 1999年 / 08期

关键词：

D O I：

10.1039/a900800d

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

(5S)-(5-tert-Butyldimethylsiloxymethyl)furan-2(5H)-one has been converted into cytosine 2',3'-dideoxy-3',5'-homocyclic monophosphate (and its 5-fluoro congener) together with an adenosine homocyclic monophosphate. These were designed as inhibitors of HIV reverse transcriptase although they did not possess such activity.

引用

页码：969 / 978

页数：10

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