CD30 in normal and neoplastic cells

被引：143

作者：

Chiarle, R ^{[1
]}

Podda, A

Prolla, G

Gong, J

Thorbecke, GJ

Inghirami, G

机构：

[1] NYU, Med Ctr, Dept Pathol, New York, NY 10016 USA

[2] NYU, Med Ctr, Kaplan Comprehens Canc Ctr, New York, NY 10016 USA

来源：

CLINICAL IMMUNOLOGY | 1999年 / 90卷 / 02期

关键词：

D O I：

10.1006/clim.1998.4636

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

In 1982 Stein and coworkers identified a new molecule, CD30 (Ki-1), which is expressed by Reed-Sternberg (RS) cells of Hodgkin's Disease (HD) (1). Although CD30 is not a specific RS cell marker, its characterization has assumed an important role not only in the differential diagnosis of HD, but also in the identification of a morphologically and clinically distinct type of large cell lymphoma, now designated as anaplastic large cell lymphoma (ALCL) (2). The cloning of human and murine CD30 and the utilization of genetically manipulated animal models have rapidly expanded our knowledge on its physiological role in lymphoid development and differentiation. The goal of this review is to present an overview of this rapidly evolving field and discuss the role of CD30 in normal and neoplastic lymphoid cells. (C) 1999 Academic Press.

引用

页码：157 / 164

页数：8

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