Applications of microbial proteases in pharmaceutical industry: an overview

被引：28
作者：
Chanalia, Preeti [1 ]
Gandhi, Dimpi [1 ]
Jodha, Drukshakshi [1 ]
Singh, Jasbir [1 ]
机构：
[1] Kurukshetra Univ, Dept Biochem, Kurukshetra 136119, Haryana, India
来源：
REVIEWS IN MEDICAL MICROBIOLOGY | 2011年 / 22卷 / 04期
关键词：
anti-inflammatory; industrial applications; pharmaceutical industry; proteases; PROTEOLYTIC-ENZYME SERRAPEPTASE; STAPHYLOCOCCUS-AUREUS; LYSOSTAPHIN TREATMENT; STREPTOKINASE; SERRATIOPEPTIDASE; ASPARAGINASE; BIOFILMS; KNEE; PAIN;
D O I：
10.1097/MRM.0b013e3283494749
中图分类号：
Q93 [微生物学];
学科分类号：
071005 ; 100705 ;
摘要：
Proteases are ubiquitous to all the living organisms. Their involvement in the life cycle of various disease causing organisms has led them to become a potential target for developing therapeutic agents against life-threatening diseases such as bacterial infection, cancer, malaria and AIDS. This review is mainly focused on the applications of microbial proteases such as serrapeptase, serrazime, lysostaphin, L-asparaginase, L-glutaminase, streptokinase, streptokinase-streptodornase and xiaflex. These enzymes are being used in the treatment of inflammation, respiratory tract disorders, cardiovascular disease and cancer. (C) 2011 Wolters Kluwer Health vertical bar Lippincott Williams & Wilkins
引用
收藏
页码：96 / 101
页数：6
相关论文
共 53 条
[1]   Effect of the proteolytic enzyme serrapeptase on swelling, pain and trismus after surgical extraction of mandibular third molars [J].
Al-Khateeb, T. H. ;
Nusair, Y. .
INTERNATIONAL JOURNAL OF ORAL AND MAXILLOFACIAL SURGERY, 2008, 37 (03) :264-268
[2]  
ALEXANDER DA, 1999, LIFE WORKS H NIEPER, P82
[3]  
ANDERSEN GD, 1999, DYNAMIC CHIROPRACTIC, V17
[4]  
Balagurunathan R., 2010, Australian Journal of Basic and Applied Sciences, V4, P698
[5]   Streptokinase - a clinically useful thrombolytic agent [J].
Banerjee, A ;
Chisti, Y ;
Banerjee, UC .
BIOTECHNOLOGY ADVANCES, 2004, 22 (04) :287-307
[6]   Staphylococci [J].
Casey, A. L. ;
Lambert, P. A. ;
Elliott, T. S. J. .
INTERNATIONAL JOURNAL OF ANTIMICROBIAL AGENTS, 2007, 29 :S23-S32
[7]  
CHIBBER BAK, 1986, J BIOL CHEM, V261, P5289
[8]   APPLICATIONS OF ALKALINE PROTEASE FROM CONIDIOBOLUS IN ANIMAL-CELL CULTURE [J].
CHIPLONKAR, JM ;
GANGODKAR, SV ;
WAGH, UV ;
GHADGE, GD ;
RELE, MV ;
SRINIVASAN, MC .
BIOTECHNOLOGY LETTERS, 1985, 7 (09) :665-668
[9]   Lysostaphin: A Staphylococcal Bacteriolysin with Potential Clinical Applications [J].
de Freire Bastos, Maria do Carmo ;
Coutinho, Bruna Goncalves ;
Varella Coelho, Marcus Livio .
PHARMACEUTICALS, 2010, 3 (04) :1139-1161
[10]   Bactericidal synergy of lysostaphin in combination with antimicrobial peptides [J].
Desbois, A. P. ;
Coote, P. J. .
EUROPEAN JOURNAL OF CLINICAL MICROBIOLOGY & INFECTIOUS DISEASES, 2011, 30 (08) :1015-1021
123456