A validation of the diathesis-stress model for depression in Generation Scotland

被引:49
作者
Arnau-Soler, Aleix [1 ,2 ]
Adams, Mark J. [3 ]
Clarke, Toni-Kim [3 ]
MacIntyre, Donald J. [3 ]
Milburn, Keith [4 ]
Navrady, Lauren [3 ]
Hayward, Caroline [5 ]
McIntosh, Andrew [3 ,6 ]
Thomson, Pippa A. [1 ,2 ]
机构
[1] Univ Edinburgh, Med Genet Sect, Ctr Genom & Expt Med, Edinburgh, Midlothian, Scotland
[2] Univ Edinburgh, MRC Inst Genet & Mol Med, Edinburgh, Midlothian, Scotland
[3] Univ Edinburgh, Royal Edinburgh Hosp, Div Psychiat, Deanery Clin Sci, Morningside Pk, Edinburgh EH10 5HF, Midlothian, Scotland
[4] Univ Dundee, Hlth Informat Ctr, Dundee, Scotland
[5] Univ Edinburgh, Inst Genet & Mol Med, Med Res Council Human Genet Unit, Edinburgh, Midlothian, Scotland
[6] Univ Edinburgh, Ctr Cognit Ageing & Cognit Epidemiol, Edinburgh, Midlothian, Scotland
基金
英国医学研究理事会; 英国惠康基金;
关键词
POLYGENIC RISK SCORES; LIFE EVENTS; ENVIRONMENT INTERACTION; DIFFERENTIAL SUSCEPTIBILITY; THREATENING EXPERIENCES; GENDER-DIFFERENCES; HEALTH; GENOME; ASSOCIATION; GENOTYPE;
D O I
10.1038/s41398-018-0356-7
中图分类号
R749 [精神病学];
学科分类号
100205 ;
摘要
Depression has well-established influences from genetic and environmental risk factors. This has led to the diathesis-stress theory, which assumes a multiplicative gene-by-environment interaction (GxE) effect on risk. Recently, Colodro-Conde et al. empirically tested this theory, using the polygenic risk score for major depressive disorder (PRS, genes) and stressful life events (SLE, environment) effects on depressive symptoms, identifying significant GxE effects with an additive contribution to liability. We have tested the diathesis-stress theory on an independent sample of 4919 individuals. We identified nominally significant positive GxE effects in the full cohort (R-2 = 0.08%, p = 0.049) and in women (R-2 = 0.19%, p = 0.017), but not in men (R-2 = 0.15%, p = 0.07). GxE effects were nominally significant, but only in women, when SLE were split into those in which the respondent plays an active or passive role (R-2 = 0.15%, p = 0.038; R-2 = 0.16%, p = 0.033, respectively). High PRS increased the risk of depression in participants reporting high numbers of SLE (p = 2.86 x 10(-4)). However, in those participants who reported no recent SLE, a higher PRS appeared to increase the risk of depressive symptoms in men (beta = 0.082, p = 0.016) but had a protective effect in women (beta = -0.061, p = 0.037). This difference was nominally significant (p = 0.017). Our study reinforces the evidence of additional risk in the aetiology of depression due to GxE effects. However, larger sample sizes are required to robustly validate these findings.
引用
收藏
页数:10
相关论文
共 72 条
[1]   Recent genomic heritage in Scotland [J].
Amador, Carmen ;
Huffman, Jennifer ;
Trochet, Holly ;
Campbell, Archie ;
Porteous, David ;
Wilson, James F. ;
Hastie, Nick ;
Vitart, Veronique ;
Hayward, Caroline ;
Navarro, Pau ;
Haley, Chris S. .
BMC GENOMICS, 2015, 16
[2]   Gender differences in depression -: Epidemiological findings from the European DEPRES I and II studies [J].
Angst, J ;
Gamma, A ;
Gastpar, M ;
Lépine, JP ;
Mendlewicz, J ;
Tylee, A .
EUROPEAN ARCHIVES OF PSYCHIATRY AND CLINICAL NEUROSCIENCE, 2002, 252 (05) :201-209
[3]  
[Anonymous], 1998, Int. J. Methods Psychiatr. Res., DOI [DOI 10.1002/MPR.47, 10.1002/mpr.47]
[4]  
Arnau Soler A., TRANSL PSYCHIAT
[5]   VALIDATION OF THE GENERAL HEALTH QUESTIONNAIRE IN A YOUNG COMMUNITY SAMPLE [J].
BANKS, MH .
PSYCHOLOGICAL MEDICINE, 1983, 13 (02) :349-353
[6]   Vulnerability genes or plasticity genes? [J].
Belsky, J. ;
Jonassaint, C. ;
Pluess, M. ;
Stanton, M. ;
Brummett, B. ;
Williams, R. .
MOLECULAR PSYCHIATRY, 2009, 14 (08) :746-754
[7]   For better and for worse:: Differential susceptibility to environmental influences [J].
Belsky, Jay ;
Bakermans-Kranenburg, Marian J. ;
van IJzendoorn, Marinus H. .
CURRENT DIRECTIONS IN PSYCHOLOGICAL SCIENCE, 2007, 16 (06) :300-304
[8]   Cumulative-genetic plasticity, parenting and adolescent self-regulation [J].
Belsky, Jay ;
Beaver, Kevin M. .
JOURNAL OF CHILD PSYCHOLOGY AND PSYCHIATRY, 2011, 52 (05) :619-626
[9]   Beyond Diathesis Stress: Differential Susceptibility to Environmental Influences [J].
Belsky, Jay ;
Pluess, Michael .
PSYCHOLOGICAL BULLETIN, 2009, 135 (06) :885-908
[10]   The Associations between Self-Reported Exposure to the Chernobyl Nuclear Disaster Zone and Mental Health Disorders in Ukraine [J].
Bolt, Matthew A. ;
Helming, Luralyn M. ;
Tintle, Nathan L. .
FRONTIERS IN PSYCHIATRY, 2018, 9