Relationship of C-reactive protein with components of the metabolic syndrome in a Tunisian population

被引:16
|
作者
Belfki, Hanen [1 ]
Ben Ali, Samir [1 ]
Bougatef, Souha [1 ]
Ben Ahmed, Decy [3 ]
Haddad, Najet [3 ]
Jmal, Awatef [2 ]
Abdennebi, Monia [2 ]
Ben Romdhane, Habiba [1 ]
机构
[1] Fac Med, Lab Epidemiol & Prevent Cardiovasc Dis, Tunis, Tunisia
[2] Mahmoud El Matri Hosp Ariana, Med Biol Lab, Tunis, Tunisia
[3] Ctr Basic Hlth Care Ariana Essoghra, Tunis, Tunisia
关键词
C-reactive protein; Metabolic syndrome; Insulin resistance; Inflammation; CORONARY-HEART-DISEASE; INSULIN-RESISTANCE; CARDIOVASCULAR-DISEASE; MAJOR DETERMINANT; ADIPOSE-TISSUE; WEIGHT-LOSS; OBESITY; RISK; ASSOCIATION; PREVALENCE;
D O I
10.1016/j.ejim.2011.10.011
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
Background: C-reactive protein (CRP) is an independent risk factor of diabetes and cardiovascular disease and it is proposed as a component of metabolic syndrome (MS). This study was undertaken to investigate the relationship between CRP and various characteristics of the MS in a sample of the Tunisian population Methods: One hundred and forty nine patients with MS and 152 controls, aged 35-70 years were recruited. Waist circumference (WC), blood pressure, HDL-cholesterol (HDL-C), triglycerides (TG), glucose, insulin and CRP were measured. Insulin resistance was assessed by homeostasis model assessment of insulin resistance (HOMA-IR). MS was defined by NCEP-ATPIII report Results: CRP levels were significantly higher in MS group (4.41 +/- 3.73 mg/L vs. 2.68 +/- 2.59 mg/L, p<0.001) compared to without MS group. For both sexes, CRP increased as the number of MS components increased (p=0.015 for men and p<0.001) after adjustment for age, smoking, alcohol intake and, for women, menopause. There were statistically significant positive correlations for log CRP with WC, log TG, and log HOMA-IR in both sexes adjusted for confounding factors listed above. A significant negative correlation was found between HDL-C and log CRP only in women. In both sexes, WC was identified, by multiple linear regression models, as significant independent predictor of CRP level variability. HDL-C showed also a significant contribution only in women Conclusions: The present study provides evidence that CRP levels are elevated in MS subjects. In addition, WC and HDL-C are significant predictors of the CRP elevation. (C) 2011 European Federation of Internal Medicine. Published by Elsevier B.V. All rights reserved.
引用
收藏
页码:E5 / E9
页数:5
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