Blocking downstream signaling pathways in the context of HDAC inhibition promotes apoptosis preferentially in cells harboring mutant Ras
被引:12
作者:
Bahr, Julian C.
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机构:
NCI, Dev Therapeut Branch, NIH, Bethesda, MD 20892 USANCI, Dev Therapeut Branch, NIH, Bethesda, MD 20892 USA
Bahr, Julian C.
[1
]
Robey, Robert W.
论文数: 0引用数: 0
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机构:
NCI, Dev Therapeut Branch, NIH, Bethesda, MD 20892 USA
NCI, Cell Biol Lab, NIH, Bethesda, MD 20892 USANCI, Dev Therapeut Branch, NIH, Bethesda, MD 20892 USA
Robey, Robert W.
[1
,2
]
Luchenko, Victoria
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机构:
NCI, Dev Therapeut Branch, NIH, Bethesda, MD 20892 USANCI, Dev Therapeut Branch, NIH, Bethesda, MD 20892 USA
Luchenko, Victoria
[1
]
Basseville, Agnes
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NCI, Dev Therapeut Branch, NIH, Bethesda, MD 20892 USANCI, Dev Therapeut Branch, NIH, Bethesda, MD 20892 USA
Basseville, Agnes
[1
]
Chakraborty, Arup R.
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NCI, Dev Therapeut Branch, NIH, Bethesda, MD 20892 USANCI, Dev Therapeut Branch, NIH, Bethesda, MD 20892 USA
Chakraborty, Arup R.
[1
]
Kozlowski, Hanna
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机构:
NCI, Cell Biol Lab, NIH, Bethesda, MD 20892 USANCI, Dev Therapeut Branch, NIH, Bethesda, MD 20892 USA
Kozlowski, Hanna
[2
]
Pauly, Gary T.
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机构:
NCI, Chem Biol Lab, Frederick Canc Res Ctr, Frederick, MD 21702 USANCI, Dev Therapeut Branch, NIH, Bethesda, MD 20892 USA
Pauly, Gary T.
[3
]
Patel, Paresma
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机构:
NCI, Chem Biol Lab, Frederick Canc Res Ctr, Frederick, MD 21702 USANCI, Dev Therapeut Branch, NIH, Bethesda, MD 20892 USA
Patel, Paresma
[3
]
Schneider, Joel P.
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机构:
NCI, Chem Biol Lab, Frederick Canc Res Ctr, Frederick, MD 21702 USANCI, Dev Therapeut Branch, NIH, Bethesda, MD 20892 USA
Schneider, Joel P.
[3
]
Gottesman, Michael M.
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机构:
NCI, Cell Biol Lab, NIH, Bethesda, MD 20892 USANCI, Dev Therapeut Branch, NIH, Bethesda, MD 20892 USA
Gottesman, Michael M.
[2
]
Bates, Susan E.
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机构:
NCI, Dev Therapeut Branch, NIH, Bethesda, MD 20892 USA
Columbia Univ, Med Ctr, Div Hematol Oncol, New York, NY 10032 USANCI, Dev Therapeut Branch, NIH, Bethesda, MD 20892 USA
Bates, Susan E.
[1
,4
]
机构:
[1] NCI, Dev Therapeut Branch, NIH, Bethesda, MD 20892 USA
[2] NCI, Cell Biol Lab, NIH, Bethesda, MD 20892 USA
[3] NCI, Chem Biol Lab, Frederick Canc Res Ctr, Frederick, MD 21702 USA
[4] Columbia Univ, Med Ctr, Div Hematol Oncol, New York, NY 10032 USA
We previously demonstrated activation of the mitogen-activated protein kinase (MAPK) pathway in a series of romidepsin-selected T-cell lymphoma cell lines as a mechanism of resistance to the histone deacetylase inhibitor (HDI), romidepsin. As Ras mutation leads to activation of both the MAPK and the phosphoinositide 3-kinase (PI3K) pathway, we examined whether combining romidepsin with small molecule pathway inhibitors would lead to increased apoptosis in cancers harboring Ras mutations. We treated 18 Ras mutant or wild-type cell lines with romidepsin in the presence of a MEK inhibitor (PD-0325901) and/or an AKT inhibitor (MK-2206) and examined apoptosis by flow cytometry. A short-term treatment schedule of romidepsin (25 ng/ml for 6 h) was used to more closely model clinical administration. Romidepsin in combination with a MEK and an AKT inhibitor induced apoptosis preferentially in cells harboring mutant versus wild-type Ras (69.1% vs. 21.1%, p < 0.0001). Similar results were found in a subset of cell lines when belinostat was combined with the MEK and AKT inhibitors and when romidepsin was combined with the dual extracellular signaling-related kinase (ERK)/PI3K inhibitor, D-87503, which inhibited both the MAPK and PI3K pathways at 5-10 mu M. The observed apoptosis was caspase-dependent and required Bak and Bax expression. Cells with wild-type or mutant Ras treated with romidepsin alone or in combination with the MEK inhibitor displayed increased expression of proapoptotic Bim. We thus conclude that cancers bearing Ras mutations, such as pancreatic cancer, can be targeted by the combination of an HDI and a dual inhibitor of the MAPK and PI3K pathways.
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Massachusetts Gen Hosp, Ctr Canc, Boston, MA 02114 USAMassachusetts Gen Hosp, Ctr Canc, Boston, MA 02114 USA
Alagesan, Brinda
;
Contino, Gianmarco
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Massachusetts Gen Hosp, Ctr Canc, Boston, MA 02114 USAMassachusetts Gen Hosp, Ctr Canc, Boston, MA 02114 USA
Contino, Gianmarco
;
Guimaraes, Alexander R.
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h-index: 0
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Massachusetts Gen Hosp, Ctr Mol Imaging Res, Boston, MA 02114 USA
Harvard Univ, Sch Med, Dept Radiol, Boston, MA 02115 USAMassachusetts Gen Hosp, Ctr Canc, Boston, MA 02114 USA
Guimaraes, Alexander R.
;
Corcoran, Ryan B.
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h-index: 0
机构:
Massachusetts Gen Hosp, Ctr Canc, Boston, MA 02114 USA
Harvard Univ, Sch Med, Dept Med, Boston, MA USAMassachusetts Gen Hosp, Ctr Canc, Boston, MA 02114 USA
Corcoran, Ryan B.
;
Deshpande, Vikram
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Massachusetts Gen Hosp, Dept Pathol, Boston, MA 02114 USA
Harvard Univ, Sch Med, Dept Pathol, Boston, MA 02115 USAMassachusetts Gen Hosp, Ctr Canc, Boston, MA 02114 USA
Deshpande, Vikram
;
Wojtkiewicz, Gregory R.
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机构:Massachusetts Gen Hosp, Ctr Canc, Boston, MA 02114 USA
Wojtkiewicz, Gregory R.
;
Hezel, Aram F.
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Massachusetts Gen Hosp, Ctr Canc, Boston, MA 02114 USA
Harvard Univ, Sch Med, Dept Med, Boston, MA USAMassachusetts Gen Hosp, Ctr Canc, Boston, MA 02114 USA
Hezel, Aram F.
;
Wong, Kwok-Kin
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机构:
Harvard Univ, Sch Med, Dept Med, Boston, MA USAMassachusetts Gen Hosp, Ctr Canc, Boston, MA 02114 USA
Wong, Kwok-Kin
;
Loda, Massimo
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h-index: 0
机构:
Harvard Univ, Sch Med, Dept Radiol, Boston, MA 02115 USA
Dana Farber Canc Inst, Dept Med Oncol, Boston, MA 02115 USA
Brigham & Womens Hosp, Dept Pathol, Boston, MA 02115 USAMassachusetts Gen Hosp, Ctr Canc, Boston, MA 02114 USA
Loda, Massimo
;
Weissleder, Ralph
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h-index: 0
机构:
Harvard Univ, Sch Med, Dept Radiol, Boston, MA 02115 USAMassachusetts Gen Hosp, Ctr Canc, Boston, MA 02114 USA
Weissleder, Ralph
;
Benes, Cyril
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机构:
Massachusetts Gen Hosp, Ctr Canc, Boston, MA 02114 USA
Harvard Univ, Sch Med, Dept Med, Boston, MA USAMassachusetts Gen Hosp, Ctr Canc, Boston, MA 02114 USA
Benes, Cyril
;
Engelman, Jeffrey A.
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机构:
Massachusetts Gen Hosp, Ctr Canc, Boston, MA 02114 USA
Harvard Univ, Sch Med, Dept Med, Boston, MA USAMassachusetts Gen Hosp, Ctr Canc, Boston, MA 02114 USA
Engelman, Jeffrey A.
;
Bardeesy, Nabeel
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Massachusetts Gen Hosp, Ctr Canc, Boston, MA 02114 USA
Harvard Univ, Sch Med, Dept Med, Boston, MA USAMassachusetts Gen Hosp, Ctr Canc, Boston, MA 02114 USA
机构:
Princess Margaret Canc Ctr, Toronto, ON, CanadaPrincess Margaret Canc Ctr, Toronto, ON, Canada
Bedard, Philippe L.
;
Tabernero, Josep
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Univ Autonoma Barcelona, Vall dHebron Univ Hosp, E-08193 Barcelona, Spain
Univ Autonoma Barcelona, Vall dHebron Inst Oncol VHIO, E-08193 Barcelona, SpainPrincess Margaret Canc Ctr, Toronto, ON, Canada
Tabernero, Josep
;
Janku, Filip
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Univ Texas MD Anderson Canc Ctr, Houston, TX 77030 USAPrincess Margaret Canc Ctr, Toronto, ON, Canada
Janku, Filip
;
Wainberg, Zev A.
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Univ Calif Los Angeles, Los Angeles, CA USAPrincess Margaret Canc Ctr, Toronto, ON, Canada
Wainberg, Zev A.
;
Paz-Ares, Luis
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Hosp Univ Virgen Rocio, Seville, SpainPrincess Margaret Canc Ctr, Toronto, ON, Canada
Paz-Ares, Luis
;
Vansteenkiste, Johan
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Univ Hosp KU Leuven, Leuven, BelgiumPrincess Margaret Canc Ctr, Toronto, ON, Canada
Vansteenkiste, Johan
;
Van Cutsem, Eric
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Univ Hosp KU Leuven, Leuven, BelgiumPrincess Margaret Canc Ctr, Toronto, ON, Canada
Van Cutsem, Eric
;
Perez-Garcia, Jose
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Princess Margaret Canc Ctr, Toronto, ON, Canada
Univ Autonoma Barcelona, Vall dHebron Univ Hosp, E-08193 Barcelona, SpainPrincess Margaret Canc Ctr, Toronto, ON, Canada
Perez-Garcia, Jose
;
Stathis, Anastasios
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Oncol Inst Southern Switzerland, Bellinzona, SwitzerlandPrincess Margaret Canc Ctr, Toronto, ON, Canada
Stathis, Anastasios
;
Britten, Carolyn D.
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Univ Calif Los Angeles, Los Angeles, CA USAPrincess Margaret Canc Ctr, Toronto, ON, Canada
Britten, Carolyn D.
;
Le, Ngocdiep
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GlaxoSmithKline, Oncol R&D, Collegeville, PA USAPrincess Margaret Canc Ctr, Toronto, ON, Canada
Le, Ngocdiep
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Carter, Kirsten
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Novartis Pharma AG, Basel, SwitzerlandPrincess Margaret Canc Ctr, Toronto, ON, Canada
Carter, Kirsten
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Demanse, David
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Novartis Pharma AG, Basel, SwitzerlandPrincess Margaret Canc Ctr, Toronto, ON, Canada
Demanse, David
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Csonka, Denes
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Novartis Pharma AG, Basel, SwitzerlandPrincess Margaret Canc Ctr, Toronto, ON, Canada
Csonka, Denes
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Peters, Malte
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Novartis Pharma AG, Basel, SwitzerlandPrincess Margaret Canc Ctr, Toronto, ON, Canada
Peters, Malte
;
Zubel, Angela
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Novartis Pharma AG, Basel, SwitzerlandPrincess Margaret Canc Ctr, Toronto, ON, Canada
Zubel, Angela
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Nauwelaerts, Heidi
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Novartis Pharma AG, Basel, SwitzerlandPrincess Margaret Canc Ctr, Toronto, ON, Canada
Nauwelaerts, Heidi
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Sessa, Cristiana
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Oncol Inst Southern Switzerland, Bellinzona, SwitzerlandPrincess Margaret Canc Ctr, Toronto, ON, Canada
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Peter MacCallum Canc Ctr, Gene Regulat Lab, Canc Therapeut Program, East Melbourne, Vic 3002, AustraliaPeter MacCallum Canc Ctr, Gene Regulat Lab, Canc Therapeut Program, East Melbourne, Vic 3002, Australia
Bolden, J. E.
;
Shi, W.
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Walter & Eliza Hall Inst Med Res, Parkville, Vic 3052, Australia
Univ Melbourne, Dept Comp & Informat Syst, Parkville, Vic 3010, AustraliaPeter MacCallum Canc Ctr, Gene Regulat Lab, Canc Therapeut Program, East Melbourne, Vic 3002, Australia
Shi, W.
;
Jankowski, K.
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Univ New S Wales, Canc Cell Dev Grp, Childrens Canc Inst Australia, Lowy Canc Ctr, Sydney, NSW 2052, AustraliaPeter MacCallum Canc Ctr, Gene Regulat Lab, Canc Therapeut Program, East Melbourne, Vic 3002, Australia
Jankowski, K.
;
Kan, C-Y
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Univ New S Wales, Canc Cell Dev Grp, Childrens Canc Inst Australia, Lowy Canc Ctr, Sydney, NSW 2052, AustraliaPeter MacCallum Canc Ctr, Gene Regulat Lab, Canc Therapeut Program, East Melbourne, Vic 3002, Australia
Kan, C-Y
;
Cluse, L.
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Peter MacCallum Canc Ctr, Gene Regulat Lab, Canc Therapeut Program, East Melbourne, Vic 3002, Australia
Univ Melbourne, Sir Peter MacCallum Dept Oncol, Parkville, Vic 3010, AustraliaPeter MacCallum Canc Ctr, Gene Regulat Lab, Canc Therapeut Program, East Melbourne, Vic 3002, Australia
Cluse, L.
;
Martin, B. P.
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Peter MacCallum Canc Ctr, Gene Regulat Lab, Canc Therapeut Program, East Melbourne, Vic 3002, Australia
Univ Melbourne, Sir Peter MacCallum Dept Oncol, Parkville, Vic 3010, AustraliaPeter MacCallum Canc Ctr, Gene Regulat Lab, Canc Therapeut Program, East Melbourne, Vic 3002, Australia
Martin, B. P.
;
MacKenzie, K. L.
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Univ New S Wales, Canc Cell Dev Grp, Childrens Canc Inst Australia, Lowy Canc Ctr, Sydney, NSW 2052, AustraliaPeter MacCallum Canc Ctr, Gene Regulat Lab, Canc Therapeut Program, East Melbourne, Vic 3002, Australia
MacKenzie, K. L.
;
Smyth, G. K.
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h-index: 0
机构:
Walter & Eliza Hall Inst Med Res, Parkville, Vic 3052, Australia
Univ Melbourne, Dept Math & Stat, Parkville, Vic 3010, AustraliaPeter MacCallum Canc Ctr, Gene Regulat Lab, Canc Therapeut Program, East Melbourne, Vic 3002, Australia
Smyth, G. K.
;
Johnstone, R. W.
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机构:
Peter MacCallum Canc Ctr, Gene Regulat Lab, Canc Therapeut Program, East Melbourne, Vic 3002, Australia
Univ Melbourne, Sir Peter MacCallum Dept Oncol, Parkville, Vic 3010, AustraliaPeter MacCallum Canc Ctr, Gene Regulat Lab, Canc Therapeut Program, East Melbourne, Vic 3002, Australia
机构:
Virginia Commonwealth Univ, Massey Canc Ctr, Richmond, VA USA
Virginia Commonwealth Univ, Dept Internal Med, Richmond, VA USAVirginia Commonwealth Univ, Massey Canc Ctr, Richmond, VA USA
机构:
Harvard Univ, Sch Med, Dana Farber Canc Inst, Howard Hughes Med Inst,Dept Pathol & Med, Boston, MA 02115 USAHarvard Univ, Sch Med, Dana Farber Canc Inst, Howard Hughes Med Inst,Dept Pathol & Med, Boston, MA 02115 USA
Harada, H
;
Quearry, B
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机构:Harvard Univ, Sch Med, Dana Farber Canc Inst, Howard Hughes Med Inst,Dept Pathol & Med, Boston, MA 02115 USA
Quearry, B
;
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Ruiz-Vela, A
;
Korsmeyer, SJ
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机构:Harvard Univ, Sch Med, Dana Farber Canc Inst, Howard Hughes Med Inst,Dept Pathol & Med, Boston, MA 02115 USA
机构:
Massachusetts Gen Hosp, Ctr Canc, Charlestown, MA 02129 USA
Harvard Univ, Sch Med, Dept Med, Boston, MA USAMassachusetts Gen Hosp, Ctr Canc, Charlestown, MA 02129 USA
Hata, Aaron N.
;
Yeo, Alan
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Massachusetts Gen Hosp, Ctr Canc, Charlestown, MA 02129 USAMassachusetts Gen Hosp, Ctr Canc, Charlestown, MA 02129 USA
Yeo, Alan
;
Faber, Anthony C.
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Massachusetts Gen Hosp, Ctr Canc, Charlestown, MA 02129 USAMassachusetts Gen Hosp, Ctr Canc, Charlestown, MA 02129 USA
Faber, Anthony C.
;
Lifshits, Eugene
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Massachusetts Gen Hosp, Ctr Canc, Charlestown, MA 02129 USAMassachusetts Gen Hosp, Ctr Canc, Charlestown, MA 02129 USA
Lifshits, Eugene
;
Chen, Zhao
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h-index: 0
机构:
Harvard Univ, Sch Med, Dept Med, Boston, MA USA
Dana Farber Canc Inst, Dept Med Oncol, Boston, MA 02115 USAMassachusetts Gen Hosp, Ctr Canc, Charlestown, MA 02129 USA
Chen, Zhao
;
Cheng, Katherine A.
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Dana Farber Canc Inst, Dept Med Oncol, Boston, MA 02115 USAMassachusetts Gen Hosp, Ctr Canc, Charlestown, MA 02129 USA
Cheng, Katherine A.
;
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Walton, Zandra
;
Sarosiek, Kristopher A.
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h-index: 0
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Dana Farber Canc Inst, Dept Med Oncol, Boston, MA 02115 USAMassachusetts Gen Hosp, Ctr Canc, Charlestown, MA 02129 USA
Sarosiek, Kristopher A.
;
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Letai, Anthony
;
Heist, Rebecca S.
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h-index: 0
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Massachusetts Gen Hosp, Ctr Canc, Charlestown, MA 02129 USA
Harvard Univ, Sch Med, Dept Med, Boston, MA USAMassachusetts Gen Hosp, Ctr Canc, Charlestown, MA 02129 USA
Heist, Rebecca S.
;
Mino-Kenudson, Mari
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Massachusetts Gen Hosp, Dept Pathol, Boston, MA 02114 USAMassachusetts Gen Hosp, Ctr Canc, Charlestown, MA 02129 USA
Mino-Kenudson, Mari
;
Wong, Kwok-Kin
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h-index: 0
机构:
Harvard Univ, Sch Med, Dept Med, Boston, MA USA
Dana Farber Canc Inst, Dept Med Oncol, Boston, MA 02115 USAMassachusetts Gen Hosp, Ctr Canc, Charlestown, MA 02129 USA
Wong, Kwok-Kin
;
Engelman, Jeffrey A.
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h-index: 0
机构:
Massachusetts Gen Hosp, Ctr Canc, Charlestown, MA 02129 USA
Harvard Univ, Sch Med, Dept Med, Boston, MA USAMassachusetts Gen Hosp, Ctr Canc, Charlestown, MA 02129 USA
机构:
Massachusetts Gen Hosp, Ctr Canc, Boston, MA 02114 USAMassachusetts Gen Hosp, Ctr Canc, Boston, MA 02114 USA
Alagesan, Brinda
;
Contino, Gianmarco
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h-index: 0
机构:
Massachusetts Gen Hosp, Ctr Canc, Boston, MA 02114 USAMassachusetts Gen Hosp, Ctr Canc, Boston, MA 02114 USA
Contino, Gianmarco
;
Guimaraes, Alexander R.
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h-index: 0
机构:
Massachusetts Gen Hosp, Ctr Mol Imaging Res, Boston, MA 02114 USA
Harvard Univ, Sch Med, Dept Radiol, Boston, MA 02115 USAMassachusetts Gen Hosp, Ctr Canc, Boston, MA 02114 USA
Guimaraes, Alexander R.
;
Corcoran, Ryan B.
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h-index: 0
机构:
Massachusetts Gen Hosp, Ctr Canc, Boston, MA 02114 USA
Harvard Univ, Sch Med, Dept Med, Boston, MA USAMassachusetts Gen Hosp, Ctr Canc, Boston, MA 02114 USA
Corcoran, Ryan B.
;
Deshpande, Vikram
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h-index: 0
机构:
Massachusetts Gen Hosp, Dept Pathol, Boston, MA 02114 USA
Harvard Univ, Sch Med, Dept Pathol, Boston, MA 02115 USAMassachusetts Gen Hosp, Ctr Canc, Boston, MA 02114 USA
Deshpande, Vikram
;
Wojtkiewicz, Gregory R.
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h-index: 0
机构:Massachusetts Gen Hosp, Ctr Canc, Boston, MA 02114 USA
Wojtkiewicz, Gregory R.
;
Hezel, Aram F.
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h-index: 0
机构:
Massachusetts Gen Hosp, Ctr Canc, Boston, MA 02114 USA
Harvard Univ, Sch Med, Dept Med, Boston, MA USAMassachusetts Gen Hosp, Ctr Canc, Boston, MA 02114 USA
Hezel, Aram F.
;
Wong, Kwok-Kin
论文数: 0引用数: 0
h-index: 0
机构:
Harvard Univ, Sch Med, Dept Med, Boston, MA USAMassachusetts Gen Hosp, Ctr Canc, Boston, MA 02114 USA
Wong, Kwok-Kin
;
Loda, Massimo
论文数: 0引用数: 0
h-index: 0
机构:
Harvard Univ, Sch Med, Dept Radiol, Boston, MA 02115 USA
Dana Farber Canc Inst, Dept Med Oncol, Boston, MA 02115 USA
Brigham & Womens Hosp, Dept Pathol, Boston, MA 02115 USAMassachusetts Gen Hosp, Ctr Canc, Boston, MA 02114 USA
Loda, Massimo
;
Weissleder, Ralph
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h-index: 0
机构:
Harvard Univ, Sch Med, Dept Radiol, Boston, MA 02115 USAMassachusetts Gen Hosp, Ctr Canc, Boston, MA 02114 USA
Weissleder, Ralph
;
Benes, Cyril
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h-index: 0
机构:
Massachusetts Gen Hosp, Ctr Canc, Boston, MA 02114 USA
Harvard Univ, Sch Med, Dept Med, Boston, MA USAMassachusetts Gen Hosp, Ctr Canc, Boston, MA 02114 USA
Benes, Cyril
;
Engelman, Jeffrey A.
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h-index: 0
机构:
Massachusetts Gen Hosp, Ctr Canc, Boston, MA 02114 USA
Harvard Univ, Sch Med, Dept Med, Boston, MA USAMassachusetts Gen Hosp, Ctr Canc, Boston, MA 02114 USA
Engelman, Jeffrey A.
;
Bardeesy, Nabeel
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h-index: 0
机构:
Massachusetts Gen Hosp, Ctr Canc, Boston, MA 02114 USA
Harvard Univ, Sch Med, Dept Med, Boston, MA USAMassachusetts Gen Hosp, Ctr Canc, Boston, MA 02114 USA
机构:
Princess Margaret Canc Ctr, Toronto, ON, CanadaPrincess Margaret Canc Ctr, Toronto, ON, Canada
Bedard, Philippe L.
;
Tabernero, Josep
论文数: 0引用数: 0
h-index: 0
机构:
Univ Autonoma Barcelona, Vall dHebron Univ Hosp, E-08193 Barcelona, Spain
Univ Autonoma Barcelona, Vall dHebron Inst Oncol VHIO, E-08193 Barcelona, SpainPrincess Margaret Canc Ctr, Toronto, ON, Canada
Tabernero, Josep
;
Janku, Filip
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h-index: 0
机构:
Univ Texas MD Anderson Canc Ctr, Houston, TX 77030 USAPrincess Margaret Canc Ctr, Toronto, ON, Canada
Janku, Filip
;
Wainberg, Zev A.
论文数: 0引用数: 0
h-index: 0
机构:
Univ Calif Los Angeles, Los Angeles, CA USAPrincess Margaret Canc Ctr, Toronto, ON, Canada
Wainberg, Zev A.
;
Paz-Ares, Luis
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h-index: 0
机构:
Hosp Univ Virgen Rocio, Seville, SpainPrincess Margaret Canc Ctr, Toronto, ON, Canada
Paz-Ares, Luis
;
Vansteenkiste, Johan
论文数: 0引用数: 0
h-index: 0
机构:
Univ Hosp KU Leuven, Leuven, BelgiumPrincess Margaret Canc Ctr, Toronto, ON, Canada
Vansteenkiste, Johan
;
Van Cutsem, Eric
论文数: 0引用数: 0
h-index: 0
机构:
Univ Hosp KU Leuven, Leuven, BelgiumPrincess Margaret Canc Ctr, Toronto, ON, Canada
Van Cutsem, Eric
;
Perez-Garcia, Jose
论文数: 0引用数: 0
h-index: 0
机构:
Princess Margaret Canc Ctr, Toronto, ON, Canada
Univ Autonoma Barcelona, Vall dHebron Univ Hosp, E-08193 Barcelona, SpainPrincess Margaret Canc Ctr, Toronto, ON, Canada
Perez-Garcia, Jose
;
Stathis, Anastasios
论文数: 0引用数: 0
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机构:
Oncol Inst Southern Switzerland, Bellinzona, SwitzerlandPrincess Margaret Canc Ctr, Toronto, ON, Canada
Stathis, Anastasios
;
Britten, Carolyn D.
论文数: 0引用数: 0
h-index: 0
机构:
Univ Calif Los Angeles, Los Angeles, CA USAPrincess Margaret Canc Ctr, Toronto, ON, Canada
Britten, Carolyn D.
;
Le, Ngocdiep
论文数: 0引用数: 0
h-index: 0
机构:
GlaxoSmithKline, Oncol R&D, Collegeville, PA USAPrincess Margaret Canc Ctr, Toronto, ON, Canada
Le, Ngocdiep
;
Carter, Kirsten
论文数: 0引用数: 0
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机构:
Novartis Pharma AG, Basel, SwitzerlandPrincess Margaret Canc Ctr, Toronto, ON, Canada
Carter, Kirsten
;
Demanse, David
论文数: 0引用数: 0
h-index: 0
机构:
Novartis Pharma AG, Basel, SwitzerlandPrincess Margaret Canc Ctr, Toronto, ON, Canada
Demanse, David
;
Csonka, Denes
论文数: 0引用数: 0
h-index: 0
机构:
Novartis Pharma AG, Basel, SwitzerlandPrincess Margaret Canc Ctr, Toronto, ON, Canada
Csonka, Denes
;
Peters, Malte
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机构:
Novartis Pharma AG, Basel, SwitzerlandPrincess Margaret Canc Ctr, Toronto, ON, Canada
Peters, Malte
;
Zubel, Angela
论文数: 0引用数: 0
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机构:
Novartis Pharma AG, Basel, SwitzerlandPrincess Margaret Canc Ctr, Toronto, ON, Canada
Zubel, Angela
;
Nauwelaerts, Heidi
论文数: 0引用数: 0
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机构:
Novartis Pharma AG, Basel, SwitzerlandPrincess Margaret Canc Ctr, Toronto, ON, Canada
Nauwelaerts, Heidi
;
Sessa, Cristiana
论文数: 0引用数: 0
h-index: 0
机构:
Oncol Inst Southern Switzerland, Bellinzona, SwitzerlandPrincess Margaret Canc Ctr, Toronto, ON, Canada
机构:
Peter MacCallum Canc Ctr, Gene Regulat Lab, Canc Therapeut Program, East Melbourne, Vic 3002, AustraliaPeter MacCallum Canc Ctr, Gene Regulat Lab, Canc Therapeut Program, East Melbourne, Vic 3002, Australia
Bolden, J. E.
;
Shi, W.
论文数: 0引用数: 0
h-index: 0
机构:
Walter & Eliza Hall Inst Med Res, Parkville, Vic 3052, Australia
Univ Melbourne, Dept Comp & Informat Syst, Parkville, Vic 3010, AustraliaPeter MacCallum Canc Ctr, Gene Regulat Lab, Canc Therapeut Program, East Melbourne, Vic 3002, Australia
Shi, W.
;
Jankowski, K.
论文数: 0引用数: 0
h-index: 0
机构:
Univ New S Wales, Canc Cell Dev Grp, Childrens Canc Inst Australia, Lowy Canc Ctr, Sydney, NSW 2052, AustraliaPeter MacCallum Canc Ctr, Gene Regulat Lab, Canc Therapeut Program, East Melbourne, Vic 3002, Australia
Jankowski, K.
;
Kan, C-Y
论文数: 0引用数: 0
h-index: 0
机构:
Univ New S Wales, Canc Cell Dev Grp, Childrens Canc Inst Australia, Lowy Canc Ctr, Sydney, NSW 2052, AustraliaPeter MacCallum Canc Ctr, Gene Regulat Lab, Canc Therapeut Program, East Melbourne, Vic 3002, Australia
Kan, C-Y
;
Cluse, L.
论文数: 0引用数: 0
h-index: 0
机构:
Peter MacCallum Canc Ctr, Gene Regulat Lab, Canc Therapeut Program, East Melbourne, Vic 3002, Australia
Univ Melbourne, Sir Peter MacCallum Dept Oncol, Parkville, Vic 3010, AustraliaPeter MacCallum Canc Ctr, Gene Regulat Lab, Canc Therapeut Program, East Melbourne, Vic 3002, Australia
Cluse, L.
;
Martin, B. P.
论文数: 0引用数: 0
h-index: 0
机构:
Peter MacCallum Canc Ctr, Gene Regulat Lab, Canc Therapeut Program, East Melbourne, Vic 3002, Australia
Univ Melbourne, Sir Peter MacCallum Dept Oncol, Parkville, Vic 3010, AustraliaPeter MacCallum Canc Ctr, Gene Regulat Lab, Canc Therapeut Program, East Melbourne, Vic 3002, Australia
Martin, B. P.
;
MacKenzie, K. L.
论文数: 0引用数: 0
h-index: 0
机构:
Univ New S Wales, Canc Cell Dev Grp, Childrens Canc Inst Australia, Lowy Canc Ctr, Sydney, NSW 2052, AustraliaPeter MacCallum Canc Ctr, Gene Regulat Lab, Canc Therapeut Program, East Melbourne, Vic 3002, Australia
MacKenzie, K. L.
;
Smyth, G. K.
论文数: 0引用数: 0
h-index: 0
机构:
Walter & Eliza Hall Inst Med Res, Parkville, Vic 3052, Australia
Univ Melbourne, Dept Math & Stat, Parkville, Vic 3010, AustraliaPeter MacCallum Canc Ctr, Gene Regulat Lab, Canc Therapeut Program, East Melbourne, Vic 3002, Australia
Smyth, G. K.
;
Johnstone, R. W.
论文数: 0引用数: 0
h-index: 0
机构:
Peter MacCallum Canc Ctr, Gene Regulat Lab, Canc Therapeut Program, East Melbourne, Vic 3002, Australia
Univ Melbourne, Sir Peter MacCallum Dept Oncol, Parkville, Vic 3010, AustraliaPeter MacCallum Canc Ctr, Gene Regulat Lab, Canc Therapeut Program, East Melbourne, Vic 3002, Australia
机构:
Virginia Commonwealth Univ, Massey Canc Ctr, Richmond, VA USA
Virginia Commonwealth Univ, Dept Internal Med, Richmond, VA USAVirginia Commonwealth Univ, Massey Canc Ctr, Richmond, VA USA
机构:
Harvard Univ, Sch Med, Dana Farber Canc Inst, Howard Hughes Med Inst,Dept Pathol & Med, Boston, MA 02115 USAHarvard Univ, Sch Med, Dana Farber Canc Inst, Howard Hughes Med Inst,Dept Pathol & Med, Boston, MA 02115 USA
Harada, H
;
Quearry, B
论文数: 0引用数: 0
h-index: 0
机构:Harvard Univ, Sch Med, Dana Farber Canc Inst, Howard Hughes Med Inst,Dept Pathol & Med, Boston, MA 02115 USA
Quearry, B
;
论文数: 引用数:
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机构:
Ruiz-Vela, A
;
Korsmeyer, SJ
论文数: 0引用数: 0
h-index: 0
机构:Harvard Univ, Sch Med, Dana Farber Canc Inst, Howard Hughes Med Inst,Dept Pathol & Med, Boston, MA 02115 USA
机构:
Massachusetts Gen Hosp, Ctr Canc, Charlestown, MA 02129 USA
Harvard Univ, Sch Med, Dept Med, Boston, MA USAMassachusetts Gen Hosp, Ctr Canc, Charlestown, MA 02129 USA
Hata, Aaron N.
;
Yeo, Alan
论文数: 0引用数: 0
h-index: 0
机构:
Massachusetts Gen Hosp, Ctr Canc, Charlestown, MA 02129 USAMassachusetts Gen Hosp, Ctr Canc, Charlestown, MA 02129 USA
Yeo, Alan
;
Faber, Anthony C.
论文数: 0引用数: 0
h-index: 0
机构:
Massachusetts Gen Hosp, Ctr Canc, Charlestown, MA 02129 USAMassachusetts Gen Hosp, Ctr Canc, Charlestown, MA 02129 USA
Faber, Anthony C.
;
Lifshits, Eugene
论文数: 0引用数: 0
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机构:
Massachusetts Gen Hosp, Ctr Canc, Charlestown, MA 02129 USAMassachusetts Gen Hosp, Ctr Canc, Charlestown, MA 02129 USA
Lifshits, Eugene
;
Chen, Zhao
论文数: 0引用数: 0
h-index: 0
机构:
Harvard Univ, Sch Med, Dept Med, Boston, MA USA
Dana Farber Canc Inst, Dept Med Oncol, Boston, MA 02115 USAMassachusetts Gen Hosp, Ctr Canc, Charlestown, MA 02129 USA
Chen, Zhao
;
Cheng, Katherine A.
论文数: 0引用数: 0
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机构:
Dana Farber Canc Inst, Dept Med Oncol, Boston, MA 02115 USAMassachusetts Gen Hosp, Ctr Canc, Charlestown, MA 02129 USA
Cheng, Katherine A.
;
论文数: 引用数:
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机构:
Walton, Zandra
;
Sarosiek, Kristopher A.
论文数: 0引用数: 0
h-index: 0
机构:
Dana Farber Canc Inst, Dept Med Oncol, Boston, MA 02115 USAMassachusetts Gen Hosp, Ctr Canc, Charlestown, MA 02129 USA
Sarosiek, Kristopher A.
;
论文数: 引用数:
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机构:
Letai, Anthony
;
Heist, Rebecca S.
论文数: 0引用数: 0
h-index: 0
机构:
Massachusetts Gen Hosp, Ctr Canc, Charlestown, MA 02129 USA
Harvard Univ, Sch Med, Dept Med, Boston, MA USAMassachusetts Gen Hosp, Ctr Canc, Charlestown, MA 02129 USA
Heist, Rebecca S.
;
Mino-Kenudson, Mari
论文数: 0引用数: 0
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机构:
Massachusetts Gen Hosp, Dept Pathol, Boston, MA 02114 USAMassachusetts Gen Hosp, Ctr Canc, Charlestown, MA 02129 USA
Mino-Kenudson, Mari
;
Wong, Kwok-Kin
论文数: 0引用数: 0
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机构:
Harvard Univ, Sch Med, Dept Med, Boston, MA USA
Dana Farber Canc Inst, Dept Med Oncol, Boston, MA 02115 USAMassachusetts Gen Hosp, Ctr Canc, Charlestown, MA 02129 USA
Wong, Kwok-Kin
;
Engelman, Jeffrey A.
论文数: 0引用数: 0
h-index: 0
机构:
Massachusetts Gen Hosp, Ctr Canc, Charlestown, MA 02129 USA
Harvard Univ, Sch Med, Dept Med, Boston, MA USAMassachusetts Gen Hosp, Ctr Canc, Charlestown, MA 02129 USA