β-C(sp2)-H alkylation of enamides using xanthate chemistry

被引：18

作者：

Bertho, Sylvain ^{[1
]}

Dondasse, Ismael ^{[1
]}

Retailleau, Pascal ^{[2
]}

Nicolas, Cyril ^{[1
]}

Gillaizeau, Isabelle ^{[1
]}

机构：

[1] Univ Orleans, Inst Organ & Analyt Chem, CNRS, ICOA,UMR 7311, Rue Chartres, F-45100 Orleans, France

[2] CNRS, Inst Chim Subst Nat, F-91198 Gif Sur Yvette, France

来源：

NEW JOURNAL OF CHEMISTRY | 2020年 / 44卷 / 17期

关键词：

RADICAL TRANSFER; FUNCTIONALIZATION; ARYLDIAZOACETATES; ALKENYLATION; ALKALOIDS; ENAMINES;

D O I：

10.1039/d0nj01209b

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Access to the gamma-amino-beta,gamma-unsaturated acyl scaffold was established by applying xanthate chemistry to enamides. This original beta-C(sp(2))-H alkylation is regioselective and exhibits broad substrate scope and good functional group tolerance. The large availability of xanthates is advantageous to the scope of the reaction which combines a radical process and a polar reaction.

引用

页码：7129 / 7141

页数：13

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