Tetramethylpyrazine Attenuates Renal Ischemia-Reperfusion Injury in Rats through Inhibiting Inflammation and Oxidative Stress and Enhancing Autophagy

被引：0

作者：

Chen, Pu ^{[1
]}

Li, Jianjun ^{[2
]}

Liu, Shuwen ^{[1
]}

Wei, Ribao ^{[1
]}

机构：

[1] Chinese Peoples Liberat Army Gen Hosp, Ctr 1, Dept Nephrol,Natl Clin Res Ctr Kidney Dis,Beijing, Chinese PLA Inst Nephrol,State Key Lab Kidney Dis, Beijing 100853, Peoples R China

[2] Beijing Univ Chinese Med, Dept Nephrol, Dongzhimen Hosp, Beijing 100700, Peoples R China

来源：

LATIN AMERICAN JOURNAL OF PHARMACY | 2020年 / 39卷 / 06期

关键词：

autophagy; inflammation; oxidative stress; renal ischemia reperfusion injury; tetramethylpyrazine; BLOOD-FLOW; TNF-ALPHA; LIGUSTRAZINE; ACTIVATION; APOPTOSIS; MODEL;

D O I：

暂无

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

In this study we evaluated the effect and mechanism of tetramethylpyrazine (TMP) on renal ischemia-reperfusion injury (RIRI) in rats. Forty-five SD rats were randomly divided into sham-operated (SO), RIRI and TMP+RIRI group, 15 rats in each group. The TMP+RIRI group was treated with 200 mg/kg TMP by intragastrical administration, once a day, for seven consecutive days. Then, the RIRI model was made in RIRI and TMP+RIRI groups. After 24 h from reperfusion, compared with RIRI group, in TMP+RIRI group the renal index and serum creatinine and blood urea nitrogen levels were decreased; the renal tissue tumor necrosis factor alpha, interleukin 1 beta and interleukin 6 levels were decreased, and the interleukin 10 level was increased; the renal tissue superoxide dismutase level was increased, and the malon-dialdehyde level was decreased; the renal tissue LC3-II/LC3-I ratio and Beclin-1/beta-actin ratio were increased. In conclusion, the TMP can attenuate the RIRI in rats through inhibiting the inflammation and oxidative stress and enhancing the autophagy in renal tissue.

引用

页码：1094 / 1099

页数：6

共 24 条

[21] Ligustrazine attenuates inflammation and the associated chemokines and receptors in ovalbumine-induced mouse asthma model [J].