Short-Term Contact Kinematic Changes and Longer-Term Biochemical Changes in the Cartilage After ACL Reconstruction: A Pilot Study

被引：13
|
作者：
Li, Guoan [1 ,2 ]
Li, Jing-Sheng [1 ,2 ,3 ]
Torriani, Martin [4 ,5 ]
Hosseini, Ali [1 ,2 ]
机构：
[1] Newton Wellesley Hosp, Orthopaed Bioengn Res Ctr, Newton, MA 02462 USA
[2] Harvard Med Sch, Newton, MA 02462 USA
[3] Boston Univ, Coll Hlth & Rehabil Sci, Boston, MA 02215 USA
[4] Massachusetts Gen Hosp, Dept Radiol, Div Musculoskeletal Imaging & Intervent, Boston, MA 02215 USA
[5] Harvard Med Sch, Boston, MA 02215 USA
来源：
ANNALS OF BIOMEDICAL ENGINEERING | 2018年 / 46卷 / 11期
基金：
美国国家卫生研究院;
关键词：
ACL; ACL reconstruction; Cartilage degeneration; Prognostic marker; Kinematics; Knee; ANTERIOR CRUCIATE LIGAMENT; PATELLAR TENDON-BONE; FOLLOW-UP; KNEE OSTEOARTHRITIS; ARTICULAR-CARTILAGE; TIBIOFEMORAL JOINT; STEP-UP; INJURY; PREVALENCE; DISEASE;
D O I：
10.1007/s10439-018-2079-6
中图分类号：
R318 [生物医学工程];
学科分类号：
0831 ;
摘要：
Investigation of the development of cartilage degeneration after ACL reconstruction is important for improving current surgical treatment of ACL injuries to prevent long-term knee joint degeneration. This pilot study examined the relationship between the changes in weight-bearing knee contact kinematics 6months after ACL reconstruction and the biochemical composition changes in the knee cartilage measured using T2 relaxation values 3years after the surgery in seven patients. The analysis indicated that the change of the knee contact kinematics in short-term after ACL reconstruction is associated with an increase of T2 values of the cartilage in longer follow up times. The data of this study could provide preliminary data to power future studies that use prospective, longitudinal research and large patient populations to establish prognostic biomechanical markers for determination of long-term cartilage degeneration after ACL reconstruction.
引用
收藏
页码：1797 / 1805
页数：9
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