Gasotransmitters in the gastrointestinal tract

被引：45

作者：

Kasparek, Michael S. ^{[1
,2
,3
]}

Linden, David R.

Kreis, Martin E. ^{[3
]}

Sarr, Michael G. ^{[1
,2
]}

机构：

[1] Mayo Clin, Coll Med, Dept Surg, Rochester, MN USA

[2] Mayo Clin, Coll Med, Gastrointestinal Res Unit, Rochester, MN USA

[3] Univ Munich, Dept Surg, Munich, Germany

来源：

SURGERY | 2008年 / 143卷 / 04期

关键词：

D O I：

10.1016/j.surg.2007.10.017

中图分类号：

R61 [外科手术学];

学科分类号：

摘要：

Mechanisms of cell-to-cell signaling take many forms: classic receptor-mediated transmission, opening and/or closing of ion channels, and this new concept of gasotransmitters that diffuse into the cell to exert their effects after being released by neural stimulation, inflammatory cells, or even bacteria. NO, CO, and H2S are the three gasotransmitters that have pioneered the latter group of signal molecules. Future work is expected to solidify our understanding of their mechanisms of action, delineate their interaction, and define their roles in normal physiology as well as pathophysiology. © 2008 Mosby, Inc. All rights reserved.

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页码：455 / 459

页数：5

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共 10 条

[1] The emerging roles of hydrogen sulfide in the gastrointestinal tract and liver [J].

Fiorucci, Stefano ;

Distrutti, Eleonora ;

Cirino, Giuseppe ;

Wallace, John L. .

GASTROENTEROLOGY, 2006, 131 (01) :259-271

[2] The role and interactions of nitric oxide (NO), carbon monoxide (CO), and prostanoids in the pathogenesis of postoperative ileus in rats [J].

Korolkiewicz, RP ;

Sein-Anand, J ;

Ruczynski, J ;

Rekowski, P ;

Bieniaszewski, L ;

Chodorowski, Z ;

Petrusewicz, J ;

Ujda, M ;

Dabkowski, J ;

Bitel, M ;

Kato, S ;

Takeuchi, K .

JOURNAL OF GASTROINTESTINAL SURGERY, 2004, 8 (03) :346-357

[3] Pharmacology of transmission to gastrointestinal muscle [J].

Lecci, A ;

Santicioli, P ;

Maggi, CA .

CURRENT OPINION IN PHARMACOLOGY, 2002, 2 (06) :630-641

[4] Hydrogen sulphide - a novel mediator of inflammation? [J].

Li, L ;

Bhatia, M ;

Moore, PK .

CURRENT OPINION IN PHARMACOLOGY, 2006, 6 (02) :125-129

[5] Haem oxygenase in enteric nervous system of human stomach and jejunum and co-localization with nitric oxide synthase [J].

Miller, SM ;

Reed, D ;

Sarr, MG ;

Farrugia, G ;

Szurszewski, JH .

NEUROGASTROENTEROLOGY AND MOTILITY, 2001, 13 (02) :121-131

[6] Hydrogen sulfide is a novel prosecretory neuromodulator in the guinea-pig and human colon [J].

Schicho, Rudolf ;

Krueger, Dagmar ;

Zeller, Florian ;

Von Weyhern, Claus Werner Hann ;

Frieling, Thomas ;

Kimura, Hideo ;

Ishii, Isao ;

De Giorgio, Roberto ;

Campi, Barbara ;

Schemann, Michael .

GASTROENTEROLOGY, 2006, 131 (05) :1542-1552

[7] Nitric oxide in liver transplantation: Pathobiology and clinical implications [J].

Shah, V ;

Kamath, PS .

LIVER TRANSPLANTATION, 2003, 9 (01) :1-11

[8] Pathophysiological significance of neuronal nitric oxide synthase in the gastrointestinal tract [J].

Takahashi, T .

JOURNAL OF GASTROENTEROLOGY, 2003, 38 (05) :421-430

[9] Two's company, three's a crowd:: can H2S be the third endogenous gaseous transmitter? [J].

Wang, R .

FASEB JOURNAL, 2002, 16 (13) :1792-1798

[10] Carbon monoxide: Endogenous production, physiological functions, and pharmacological applications [J].

Wu, LY ;

Wang, R .

PHARMACOLOGICAL REVIEWS, 2005, 57 (04) :585-630