Gasotransmitters in the gastrointestinal tract

被引：45
作者：
Kasparek, Michael S. [1 ,2 ,3 ]
Linden, David R.
Kreis, Martin E. [3 ]
Sarr, Michael G. [1 ,2 ]
机构：
[1] Mayo Clin, Coll Med, Dept Surg, Rochester, MN USA
[2] Mayo Clin, Coll Med, Gastrointestinal Res Unit, Rochester, MN USA
[3] Univ Munich, Dept Surg, Munich, Germany
来源：
SURGERY | 2008年 / 143卷 / 04期
关键词：
D O I：
10.1016/j.surg.2007.10.017
中图分类号：
R61 [外科手术学];
学科分类号：
摘要：
Mechanisms of cell-to-cell signaling take many forms: classic receptor-mediated transmission, opening and/or closing of ion channels, and this new concept of gasotransmitters that diffuse into the cell to exert their effects after being released by neural stimulation, inflammatory cells, or even bacteria. NO, CO, and H2S are the three gasotransmitters that have pioneered the latter group of signal molecules. Future work is expected to solidify our understanding of their mechanisms of action, delineate their interaction, and define their roles in normal physiology as well as pathophysiology. © 2008 Mosby, Inc. All rights reserved.
引用
收藏
页码：455 / 459
页数：5
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