Monoterpene Alkaloids from Incarvillea delavayi Bureau et Franchet and Their Inhibition against LPS Induced NO Production in BV2 Cells

被引：2

作者：

Shen, Xiu-Ping ^{[1
]}

Chen, Hong ^{[2
]}

Li, Shan-Shan ^{[1
]}

Li, Jia-Yu ^{[3
]}

Li, Xu ^{[1
]}

Zu, Xian-Peng ^{[2
]}

Xu, Xi-Ke ^{[2
]}

Li, Xian ^{[1
]}

Shen, Yun-Heng ^{[2
]}

机构：

[1] Kunming Med Univ, Sch Pharm, Kunming 650500, Yunnan, Peoples R China

[2] Naval Med Univ, Sch Pharm, Shanghai 200433, Peoples R China

[3] Fujian Univ Tradit Chinese Med, Coll Tradit Chinese Med, Fuzhou 350000, Peoples R China

来源：

CHEMISTRY & BIODIVERSITY | 2022年 / 19卷 / 03期

关键词：

Incarvillea delavayi; monoterpene alkaloid; X-ray diffraction; NMR calculation; nitric oxide; BV2; cell; SESQUITERPENE; UNIQUE; ESTER; DIMER;

D O I：

10.1002/cbdv.202101013

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Three new monoterpene alkaloids, delavatines C-E (1-3), along with five known ones (4-8), were separated from the whole plants of Incarvillea delavayi. All compounds were deduced by interpretation of comprehensive NMR spectral data and X-Ray single crystal diffraction, in combination with a quantum chemical calculation of NMR chemical shift coupled with an advanced statistical procedure DP4+. Compounds 1-8 were assessed NO suppressive effect in LPS-stimulated BV2 microglia cells. Compounds 2, 3, 6, and 8 exhibited significant inhibition against NO production in LPS-induced BV2 cells with IC50 values of 25.62, 17.29, 19.94 and 23.88 mu M, stronger than or comparable to the positive control (AG) with IC50 value of 26.13 mu M.

引用

页数：10

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