Monoterpene Alkaloids from Incarvillea delavayi Bureau et Franchet and Their Inhibition against LPS Induced NO Production in BV2 Cells

被引：2
作者：
Shen, Xiu-Ping [1 ]
Chen, Hong [2 ]
Li, Shan-Shan [1 ]
Li, Jia-Yu [3 ]
Li, Xu [1 ]
Zu, Xian-Peng [2 ]
Xu, Xi-Ke [2 ]
Li, Xian [1 ]
Shen, Yun-Heng [2 ]
机构：
[1] Kunming Med Univ, Sch Pharm, Kunming 650500, Yunnan, Peoples R China
[2] Naval Med Univ, Sch Pharm, Shanghai 200433, Peoples R China
[3] Fujian Univ Tradit Chinese Med, Coll Tradit Chinese Med, Fuzhou 350000, Peoples R China
来源：
CHEMISTRY & BIODIVERSITY | 2022年 / 19卷 / 03期
关键词：
Incarvillea delavayi; monoterpene alkaloid; X-ray diffraction; NMR calculation; nitric oxide; BV2; cell; SESQUITERPENE; UNIQUE; ESTER; DIMER;
D O I：
10.1002/cbdv.202101013
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Three new monoterpene alkaloids, delavatines C-E (1-3), along with five known ones (4-8), were separated from the whole plants of Incarvillea delavayi. All compounds were deduced by interpretation of comprehensive NMR spectral data and X-Ray single crystal diffraction, in combination with a quantum chemical calculation of NMR chemical shift coupled with an advanced statistical procedure DP4+. Compounds 1-8 were assessed NO suppressive effect in LPS-stimulated BV2 microglia cells. Compounds 2, 3, 6, and 8 exhibited significant inhibition against NO production in LPS-induced BV2 cells with IC50 values of 25.62, 17.29, 19.94 and 23.88 mu M, stronger than or comparable to the positive control (AG) with IC50 value of 26.13 mu M.
引用
收藏
页数：10
相关论文
共 50 条
  • [21] Alkaloids from Chelidonium majus and their inhibitory effects on LPS-induced NO production in RAW264.7 cells
    Park, Ji Eun
    Cuong, To Dao
    Tran Manh Hung
    Lee, IkSoo
    Na, MinKyun
    Kim, Jin Cheol
    Ryoo, SungWoo
    Lee, Jeong Hyung
    Choi, Jae Sue
    Woo, Mi Hee
    Min, Byung Sun
    BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 2011, 21 (23) : 6960 - 6963
  • [22] Down-regulation of BNIP3 by olomoucine, a CDK inhibitor, reduces LPS- and NO-induced cell death in BV2 microglial cells
    Tsou, Yu-Chi
    Wang, Hsiao-Hsien
    Hsieh, Chii-Cheng
    Sun, Kuang-Hui
    Sun, Guang-Huan
    Jhou, Ren-Shiang
    Liu, Tz-I
    Lu, Shou-Yun
    Liu, Huan-Yun
    Tang, Shye-Jye
    NEUROSCIENCE LETTERS, 2016, 628 : 186 - 193
  • [23] Cyanidin-3-O-Glucoside Protects PC12 Cells Against Neuronal Apoptosis Mediated by LPS-Stimulated BV2 Microglial Activation
    Kaewmool, Chayanut
    Udomruk, Sasimol
    Phitak, Thanyaluck
    Pothacharoen, Peraphan
    Kongtawelert, Prachya
    NEUROTOXICITY RESEARCH, 2020, 37 (01) : 111 - 125
  • [24] Inhibitory constituents of lipopolysaccharide-induced nitric oxide production in BV2 microglia isolated from Amomum tsao-ko
    Lee, Ki Yong
    Kim, Seung Hyun
    Sung, Sang Hyun
    Kim, Young Choong
    PLANTA MEDICA, 2008, 74 (08) : 867 - 869
  • [25] Taurine Chloramine Suppresses LPS-Induced Neuroinflammatory Responses through Nrf2-Mediated Heme Oxygenase-1 Expression in Mouse BV2 Microglial Cells
    Lee, Dong-Sung
    Kwon, Ki Han
    Cheong, Sun Hee
    TAURINE 10, 2017, 975 : 131 - 143
  • [26] Anti-inflammatory effects of Polygala tenuifolia root through inhibition of NF-κB activation in lipopolysaccharide-induced BV2 microglial cells
    Cheong, Myung-Hee
    Lee, Sang-Ryong
    Yoo, Hwa-Seung
    Jeong, Jin-Woo
    Kim, Gi-Young
    Kim, Wun-Jae
    Jung, In-Chul
    Choi, Yung Hyun
    JOURNAL OF ETHNOPHARMACOLOGY, 2011, 137 (03) : 1402 - 1408
  • [27] Anti-inflammatory effects of fucoidan through inhibition of NF-κB, MAPK and Akt activation in lipopolysaccharide-induced BV2 microglia cells
    Park, Hye Young
    Han, Min Ho
    Park, Cheol
    Jin, Cheng-Yun
    Kim, Gi-Young
    Choi, Il-Whan
    Kim, Nam Deuk
    Nam, Taek-Jeong
    Kwon, Taeg Kyu
    Choi, Yung Hyun
    FOOD AND CHEMICAL TOXICOLOGY, 2011, 49 (08) : 1745 - 1752
  • [28] Antagonistic effects of acetylshikonin on LPS-induced NO and PGE2 production in BV2 microglial cells via inhibition of ROS/PI3K/Akt-mediated NF-κB signaling and activation of Nrf2-dependent HO-1
    Jayasooriya, Rajapaksha Gedara Prasad Tharanga
    Lee, Kyoung-Tae
    Choi, Yung Hyun
    Moon, Sung-Kwon
    Kim, Wun-Jae
    Kim, Gi-Young
    IN VITRO CELLULAR & DEVELOPMENTAL BIOLOGY-ANIMAL, 2015, 51 (09) : 975 - 986
  • [29] Antagonistic effects of acetylshikonin on LPS-induced NO and PGE2 production in BV2 microglial cells via inhibition of ROS/PI3K/Akt-mediated NF-κB signaling and activation of Nrf2-dependent HO-1
    Rajapaksha Gedara Prasad Tharanga Jayasooriya
    Kyoung-Tae Lee
    Yung Hyun Choi
    Sung-Kwon Moon
    Wun-Jae Kim
    Gi-Young Kim
    In Vitro Cellular & Developmental Biology - Animal, 2015, 51 : 975 - 986
  • [30] Cynandione A from Cynanchum wilfordii Attenuates the Production of Inflammatory Mediators in LPS-Induced BV-2 Microglial Cells via NF-κB Inactivation
    Yang, Seung Bo
    Lee, Sang Min
    Park, Ji-Hae
    Lee, Tae Hoon
    Baek, Nam-In
    Park, Hi-Joon
    Lee, Hyejung
    Kim, Jiyoung
    BIOLOGICAL & PHARMACEUTICAL BULLETIN, 2014, 37 (08) : 1390 - 1396
12345