Human FOXP3+ Regulatory T Cell Heterogeneity and Function in Autoimmunity and Cancer

被引：550
作者：
Wing, James B. [1 ]
Tanaka, Atsushi [1 ]
Sakaguchi, Shimon [1 ,2 ]
机构：
[1] Osaka Univ, Immunol Frontier Res Ctr, Lab Expt Immunol, Suita, Osaka 5650871, Japan
[2] Kyoto Univ, Inst Frontier Med Sci, Dept Expt Pathol, Kyoto 6068507, Japan
来源：
IMMUNITY | 2019年 / 50卷 / 02期
关键词：
TUMOR-INFILTRATING LYMPHOCYTES; IMMUNE DYSREGULATION; SELF-TOLERANCE; SUPPRESSIVE FUNCTION; EPIGENETIC CHANGES; FAMILY-MEMBER; CIS-ELEMENT; TREG CELLS; EXPRESSION; RECEPTOR;
D O I：
10.1016/j.immuni.2019.01.020
中图分类号：
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号：
100102 ;
摘要：
Regulatory T (Treg) cells expressing the transcription factor Foxp3 have a critical role in the maintenance of immune homeostasis and prevention of autoimmunity. Recent advances in single cell analyses have revealed a range of Treg cell activation and differentiation states in different human pathologies. Here we review recent progress in the understanding of human Treg cell heterogeneity and function. We discuss these findings within the context of concepts in Treg cell development and function derived from preclinical models and insight from approaches targeting Treg cells in clinical settings. Distinguishing functional Treg cells from other T cells and understanding the context-dependent function(s) of different Treg subsets will be crucial to the development of strategies toward the selective therapeutic manipulation of Treg cells in autoimmunity and cancer.
引用
收藏
页码：302 / 316
页数：15
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