Apigenin: A dietary flavonoid with diverse anticancer properties

被引：281

作者：

Madunic, Josip ^{[1
]}

Madunic, Ivana Vrhovac ^{[2
]}

Gajski, Goran ^{[3
]}

Popic, Jelena ^{[4
]}

Garaj-Vrhovac, Vera ^{[3
]}

机构：

[1] Univ Zagreb, Fac Sci, Dept Biol, Div Mol Biol, Horvatovac 102A, Zagreb 10000, Croatia

[2] Inst Med Res & Occupat Hlth, Mol Toxicol Unit, Ksaverska Cesta 2, Zagreb 10000, Croatia

[3] Inst Med Res & Occupat Hlth, Mutagenesis Unit, Ksaverska Cesta 2, Zagreb 10000, Croatia

[4] Clin Hosp Merkur, Dept Diagnost & Intervent Radiol, Zajceva 19, Zagreb 10000, Croatia

来源：

CANCER LETTERS | 2018年 / 413卷

关键词：

Apigenin; Anticancer activity; Apoptosis; Cell cycle arrest; Signalling pathways; SQUAMOUS-CELL CARCINOMA; CASPASE-DEPENDENT APOPTOSIS; BREAST-CANCER CELLS; SK-N-DZ; OXIDATIVE STRESS; CRUCIFEROUS VEGETABLES; INHIBITS PROLIFERATION; GLUT-1; EXPRESSION; DRUG-INTERACTIONS; HTERT KNOCKDOWN;

D O I：

10.1016/j.canlet.2017.10.041

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Apigenin is a natural flavonoid found in several dietary plant foods such as vegetables and fruits. A large number of studies conducted over the past years have shown that this particular natural compound has potential antioxidant, anti-inflammatory, and anticancer properties. Therefore, apigenin has generated a great deal of interest as a possible chemotherapeutic modality due to its low intrinsic toxicity and remarkable effects on normal versus cancerous cells, compared with other structurally related flavonoids. Here, we review its role in anticancer research, as well as several cancer signalling pathways, including MAPK, PI3K/Akt and NF-kappa B pathways, and their specific role in different cancer types. Based on the available literature, the beneficial effects of apigenin as a future anticancer modality are promising but they require further in vitro and in vivo studies to enable its translation from bench to bedside. (c) 2017 Elsevier B.V. All rights reserved.

引用

页码：11 / 22

页数：12

共 117 条

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