Implantable Sufficiently Integrated Multimodal Flexible Sensor for Intracranial Monitoring

被引：32

作者：

Liu, Tiezhu ^{[1
,2
]}

Yao, Pan ^{[1
,2
]}

Li, Zhou ^{[3
,4
]}

Feng, Hongqing ^{[3
,4
]}

Zhuang, Chengyu ^{[5
]}

Sun, Xuan ^{[6
]}

Liu, Chunxiu ^{[1
,2
]}

Xue, Ning ^{[1
,2
]}

机构：

[1] Aerosp Informat Res Inst AIR, State Key Lab Transducer Technol, Beijing, Peoples R China

[2] Univ Chinese Acad Sci, Sch Elect Elect & Commun Engn, Beijing, Peoples R China

[3] Chinese Acad Sci, CAS Ctr Excellence Nanosci, Beijing Inst Nanoenergy & Nanosyst, Beijing Key Lab Micronano Energy & Sensor, Beijing, Peoples R China

[4] Univ Chinese Acad Sci, Sch Nanosci & Technol, Beijing, Peoples R China

[5] Shanghai Jiao Tong Univ, Ruijin Hosp, Shanghai Inst Traumatol & Orthopaed, Dept Orthopaed,Sch Med,Shanghai Key Lab Prevent &, Shanghai, Peoples R China

[6] Capital Med Univ, Beijing Tiantan Hosp, Intervent Neuroradiol Ctr, Beijing, Peoples R China

来源：

2021 IEEE SENSORS | 2021年

基金：

国家重点研发计划; 中国国家自然科学基金;

关键词：

integration; intracranial; physiology; biochemistry; flexible sensor; TRAUMATIC BRAIN-INJURY;

D O I：

10.1109/SENSORS47087.2021.9639547

中图分类号：

TM [电工技术]; TN [电子技术、通信技术];

学科分类号：

0808 ; 0809 ;

摘要：

Traumatic brain injury (TBI) is a global health problem, and real-time monitoring of intracranial physiological and biochemical information in patients with TBI remains a challenge. In this study, we report a flexible multimodal sensor based on polyimide, which has the potential to be implanted into the skull to measure cerebral cortical discharge, intracranial temperature, brain tissue oxygen content, sodium and potassium in cerebrospinal fluid, and intracranial pressure. In addition, this sensor has good flexibility and can be implanted into the brain smoothly. The proposed technique provides a novel insight for real-time monitoring of intracranial physiological and biochemical information and is of great significance for the diagnosis of TBI.

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