Nanofibrillar Patches of Commensal Skin Bacteria

被引：11

作者：

Glinel, Karine ^{[1
,2
]}

Behrens, Adam ^{[2
]}

Langer, Robert S. ^{[2
]}

Jaklenec, Ana ^{[2
]}

Jonas, Alain M. ^{[1
,2
]}

机构：

[1] Catholic Univ Louvain, Inst Condensed Matter & Nanosci, Croix Sud 1-L7-04-02, B-1348 Louvain La Neuve, Belgium

[2] MIT, David H Koch Inst Integrat Canc Res, 500 Main St, Cambridge, MA 02139 USA

来源：

BIOMACROMOLECULES | 2019年 / 20卷 / 01期

关键词：

STAPHYLOCOCCUS-EPIDERMIDIS; NANOTUBES; FABRICATION; FILMS;

D O I：

10.1021/acs.biomac.8b00735

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

We demonstrate entrapment of the commensal skin bacteria Staphylococcus epidermidis in mats composed of soft nanotubes made by membrane-templated layer-by-layer (LbL) assembly. When cultured in broth, the resulting nanofibrillar patches efficiently delay the escape of bacteria and their planktonic growth, while displaying high steady-state metabolic activity. Additionally, the material properties and metabolic activity can be further tuned by postprocessing the patches with additional polysaccharide LbL layers. These patches offer a promising methodology for the fabrication of bacterial skin dressings for the treatment of skin dysbiosis while preventing adverse effects due to bacterial proliferation.

引用

页码：102 / 108

页数：7

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