Nutritional factors and Alzheimer's disease

被引：57

作者：

Reynish, W ^{[1
]}

Andrieu, S ^{[1
]}

Nourhashemi, F ^{[1
]}

Vellas, B ^{[1
]}

机构：

[1] Univ Hosp Toulouse, Dept Clin Gerontol & Internal Med, Toulouse, France

来源：

JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES | 2001年 / 56卷 / 11期

关键词：

D O I：

10.1093/gerona/56.11.M675

中图分类号：

R592 [老年病学]; C [社会科学总论];

学科分类号：

03 ; 0303 ; 100203 ;

摘要：

Nutritional factors are integrally linked with Alzheimer's disease (AD). Although AD patients have no changes in energy metabolism, fluctuations in weight are fairly common. The potential role of vitamin B-12 and folate, with the production of hyperhomocysteinemia, in the pathophysiology of AD is explored. The role of free-radical damage in AD is discussed. It is stressed that alterations in dietary lipids may play an important role in cognitive defects in AD secondary to their effects on neuronal membrane lipids. More research is needed on the role of nutrition in the ongoing development of cognitive changes in AD.

引用

页码：M675 / M680

页数：6

共 65 条

[1]

Alzheimer A., 1907, ALLG Z PSYCHIAT, V64, P146, DOI DOI 10.1002/CA.980080612

[2] WOMEN, MYOCARDIAL-INFARCTION, AND DEMENTIA IN THE VERY OLD [J].

ARONSON, MK ;

OOI, WL ;

MORGENSTERN, H ;

HAFNER, A ;

MASUR, D ;

CRYSTAL, H ;

FRISHMAN, WH ;

FISHER, D ;

KATZMAN, R .

NEUROLOGY, 1990, 40 (07) :1102-1106

[3] Weight loss precedes dementia in community-dwelling older adults [J].

BarrettConnor, E ;

Edelstein, SL ;

CoreyBloom, J ;

Wiederholt, WC .

JOURNAL OF THE AMERICAN GERIATRICS SOCIETY, 1996, 44 (10) :1147-1152

[4] COBALAMIN LEVELS ARE NOT REDUCED IN ALZHEIMERS-DISEASE - RESULTS FROM A POPULATION-BASED STUDY [J].

BASUN, H ;

FRATIGLIONI, L ;

WINBLAD, B .

JOURNAL OF THE AMERICAN GERIATRICS SOCIETY, 1994, 42 (02) :132-136

[5] Apoptosis and Alzheimer's disease [J].

Behl, C .

JOURNAL OF NEURAL TRANSMISSION, 2000, 107 (11) :1325-1344

[6]

Bodovitz S, 1996, J BIOL CHEM, V271, P4436

[7]

Breteler MMB, 1998, HAEMOSTASIS, V28, P167

[8] DIETARY-INTAKE AND CLINICAL, ANTHROPOMETRIC AND BIOCHEMICAL INDEXES OF MALNUTRITION IN ELDERLY DEMENTED PATIENTS AND NON-DEMENTED SUBJECTS [J].

BURNS, A ;

MARSH, A ;

BENDER, DA .

PSYCHOLOGICAL MEDICINE, 1989, 19 (02) :383-391

[9] Folate, vitamin B12, and serum total homocysteine levels in confirmed Alzheimer disease [J].

Clarke, R ;

Smith, AD ;

Jobst, KA ;

Refsum, H ;

Sutton, L ;

Ueland, PM .

ARCHIVES OF NEUROLOGY, 1998, 55 (11) :1449-1455

[10] EFFECTS OF TREATMENT WITH SIMVASTATIN AND PRAVASTATIN ON COGNITIVE FUNCTION IN PATIENTS WITH HYPERCHOLESTEROLEMIA [J].

CUTLER, N ;

SRAMEK, J ;

VEROFF, A ;

BLOCK, G ;

STAUFFER, L ;

LINES, C .

BRITISH JOURNAL OF CLINICAL PHARMACOLOGY, 1995, 39 (03) :333-336

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