Molecular Characterization of Newly Emerged blaKPC-2-Producing Klebsiella pneumoniae in Singapore

被引：44

作者：

Balm, Michelle N. D. ^{[1
]}

Ngan, Grace ^{[1
]}

Jureen, Roland ^{[1
]}

Lin, Raymond T. P. ^{[1
]}

Teo, Jeanette ^{[1
]}

机构：

[1] Natl Univ Singapore Hosp, Dept Lab Med, Singapore 117548, Singapore

来源：

JOURNAL OF CLINICAL MICROBIOLOGY | 2012年 / 50卷 / 02期

关键词：

D O I：

10.1128/JCM.05914-11

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

In Asia, bla(KPC) detection has been limited to East Asia and not yet seen in Southeast Asia. We report four bla(KPC-2)-containing Klebsiella pneumoniae isolates from two different hospitals in Singapore. All isolates belonged to strain type 11 (ST11) and were indistinguishable by pulsed-field gel electrophoresis (PFGE). bla(KPC-2) was located on nonconjugative plasmids and flanked by mobile genetic structures composed of a partial Tn4401 transposon and a Tn3-based transposon which previously have been described only in Chinese isolates.

引用

页码：475 / 476

页数：2

共 13 条

[1] A GENERAL-METHOD FOR DETECTING AND SIZING LARGE PLASMIDS [J].

BARTON, BM ;

HARDING, GP ;

ZUCCARELLI, AJ .

ANALYTICAL BIOCHEMISTRY, 1995, 226 (02) :235-240

[2] Arrival of Klebsiella pneumoniae carbapenemase (KPC)-2 in Taiwan [J].

Chung, Kuei-Pin ;

Tseng, Sung-Pin ;

Huang, Yu-Tsung ;

Tsai, Tzu-Hsiu ;

Teng, Lee-Jene ;

Hsueh, Po-Ren .

JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY, 2011, 66 (05) :1182-1184

[3] Worldwide Diversity of Klebsiella pneumoniae That Produces β-Lactamase blaKPC-2 Gene [J].

Cuzon, Gaelle ;

Naas, Thierry ;

Truong, HaVy ;

Villegas, Maria-Virginia ;

Wisell, Karin T. ;

Carmeli, Yehuda ;

Gales, Ana C. ;

Navon-Venezia, Shiri ;

Quinn, John P. ;

Nordmann, Patrice .

EMERGING INFECTIOUS DISEASES, 2010, 16 (09) :1349-1356

[4] Emergence of Klebsiella pneumoniae ST258 with KPC-2 in Hong Kong [J].

Ho, P. -L. ;

Tse, C. W. S. ;

Lai, E. L. ;

Lo, W. U. ;

Chow, K. H. .

INTERNATIONAL JOURNAL OF ANTIMICROBIAL AGENTS, 2011, 37 (04) :386-387

[5] Molecular understanding of aminoglycoside action and resistance [J].

Jana, S ;

Deb, JK .

APPLIED MICROBIOLOGY AND BIOTECHNOLOGY, 2006, 70 (02) :140-150

[6]

Kaufmann Mary Elizabeth, 1998, V15, P33

[7]

Koh TH, 2008, ANN ACAD MED SINGAP, V37, P847

[8] Novel genetic environment of the plasmid-mediated KPC-3 gene detected in Escherichia coli and Citrobacter freundii isolates from China [J].

Li, G. ;

Wei, Q. ;

Wang, Y. ;

Du, X. ;

Zhao, Y. ;

Jiang, X. .

EUROPEAN JOURNAL OF CLINICAL MICROBIOLOGY & INFECTIOUS DISEASES, 2011, 30 (04) :575-580

[9] Genetic structures at the origin of acquisition of the β-lactamase blaKPC gene [J].

Naas, Thierry ;

Cuzon, Gaelle ;

Villegas, Maria-Virginia ;

Lartigue, Marie-Frederique ;

Quinn, John P. ;

Nordmann, Patrice .

ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, 2008, 52 (04) :1257-1263

[10] ST11, the dominant clone of KPC-producing Klebsiella pneumoniae in China [J].

Qi, Yan ;

Wei, Zeqing ;

Ji, Shujuan ;

Du, Xiaoxing ;

Shen, Ping ;

Yu, Yunsong .

JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY, 2011, 66 (02) :307-312

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