Flumequine in the goat: Pharmacokinetics after intravenous and intramuscular administration

The pharmacokinetics or flumequine, administered intravenously and intramuscularly at a single dose of 20 mg/kg, was investigated in healthy goats. After intravenous injection, flumequine distributed rapidly (t(1/2)alpha = 0.87 +/- 0.15 h) but was eliminated slowly (t(1/2 beta) = 7.12 +/- 1.27 h) mean clearance (Cl) and volume of distribution (V-dss) were 0.32 +/- 0.03 (L/(h.kg) and 1.22 +/- 029 (L/kg), respectively After intramuscular administration, the peak serum concentration (C-max = 7.40 +/- 0.5 mu g/ml) was reached in about 1.5 h (T-max) and bioavailability was about 93%. Estimated flumequine serum levels following repeated intramuscular administration of the aqueous Suspension used in the study (7.23 +/- 0.7 mu g/ml and 4.82 +/- 0.47 mu g/ml at intervals of 8 anti 12 h, respective]),) indicated that to maintain serum levels above MIC values for susceptible bacteria a dosage regimen of 20 mg/kg every 12 h is necessary by the intramuscular route.