Novel pharmacological therapies for irritable bowel syndrome

被引：20

作者：

Corsetti, Maura ^{[1
]}

Whorwell, Peter ^{[2
]}

机构：

[1] Univ Leuven, Translat Res Ctr Gastrointestinal Disorders TARGI, Leuven, Belgium

[2] Univ Manchester, Ctr Gastrointestinal Sci, Manchester, Lancs, England

来源：

EXPERT REVIEW OF GASTROENTEROLOGY & HEPATOLOGY | 2016年 / 10卷 / 07期

关键词：

IBS treatment; pain; diarrhea; constipation; PLACEBO-CONTROLLED TRIAL; CHRONIC IDIOPATHIC CONSTIPATION; QUALITY-OF-LIFE; VISCERAL HYPERSENSITIVITY; REDUCES SYMPTOMS; ABDOMINAL-PAIN; DOUBLE-BLIND; DIARRHEA; SAFETY; LINACLOTIDE;

D O I：

10.1586/17474124.2016.1158099

中图分类号：

R57 [消化系及腹部疾病];

学科分类号：

摘要：

Irritable bowel syndrome (IBS) is a prevalent functional gastrointestinal disorder, which represents a major cost to healthcare services. Current pharmacological treatment includes fibre supplements, antispasmodics, laxatives, loperamide and antidepressants. This article reviews the novel pharmacological treatments already or recently approved for patients with IBS-C (lubiprostone, linaclotide) and IBSD (alosetron, ramosetron, rifaximin, eluxadoline). Furthermore, results for drugs in development (plecanatide, ibudutant and ebastine) or used in chronic constipation or for other indications, with potential application in IBS (prucalopride, elobixibat, mesalazine, ondansetron and colesevelam) are also reviewed.

引用

页码：807 / 815

页数：9

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