Oncolytic Newcastle disease virus for cancer therapy: old challenges and new directions

被引：2

作者：

Zamarin, Dmitriy ^{[1
]}

Palese, Peter ^{[1
]}

机构：

[1] Mt Sinai Sch Med, Dept Microbiol, New York, NY 10029 USA

来源：

FUTURE MICROBIOLOGY | 2012年 / 7卷 / 03期

关键词：

apoptosis; cancer; immunotherapy; interferon; NDV; oncolytic; TUMOR-CELL VACCINE; EHRLICH ASCITES TUMOR; ACTIVE SPECIFIC IMMUNOTHERAPY; HEMAGGLUTININ-NEURAMINIDASE PROTEIN; BISPECIFIC FUSION PROTEIN; APOPTOSIS-INDUCING LIGAND; SELECTIVE GENE-TRANSFER; II MALIGNANT-MELANOMA; AVIAN INFLUENZA-VIRUS; COLORECTAL-CANCER;

D O I：

10.2217/FMB.12.4

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

Newcastle disease virus (NDV) is an avian paramyxovirus, which has been demonstrated to possess significant oncolytic activity against mammalian cancers. This review summarizes the research leading to the elucidation of the mechanisms of NDV-mediated oncolysis, as well as the development of novel oncolytic agents through the use of genetic engineering. Clinical trials utilizing NDV strains and NDV-based autologous tumor cell vaccines will expand our knowledge of these novel anticancer strategies and will ultimately result in the successful use of the virus in the clinical setting.

引用

页码：347 / 367

页数：21

共 191 条

[61] An optimized clinical regimen for the oncolytic virus PV701 [J].

Hotte, Sebastien J. ;

Lorence, Robert M. ;

Hirte, Hal W. ;

Polawski, Susan R. ;

Bamat, Michael K. ;

O'Neil, James D. ;

Roberts, M. Scot ;

Groene, William S. ;

Major, Pierre P. .

CLINICAL CANCER RESEARCH, 2007, 13 (03) :977-985

[62] The cytotoxic anti-tumor effect of MTH-68/H, a live attenuated Newcastle disease virus is mediated by the induction of nitric oxide synthesis in rat peritoneal macrophages in vitro [J].

Hrabák, A ;

Csuka, I ;

Bajor, T ;

Csatáry, LK .

CANCER LETTERS, 2006, 231 (02) :279-289

[63] The hemagglutinin-neuraminidase protein of Newcastle disease virus determines tropism and virulence [J].

Huang, ZH ;

Panda, A ;

Elankumaran, S ;

Govindarajan, D ;

Rockemann, DD ;

Samal, SK .

JOURNAL OF VIROLOGY, 2004, 78 (08) :4176-4184

[64] Newcastle disease virus V protein is associated with viral pathogenesis and functions as an alpha interferon antagonist [J].

Huang, ZH ;

Krishnamurthy, S ;

Panda, A ;

Samal, SK .

JOURNAL OF VIROLOGY, 2003, 77 (16) :8676-8685

[65] Oral tolerization to adenoviral proteins permits repeated adenovirus-mediated gene therapy in rats with pre-existing immunity to adenoviruses [J].

Ilan, Y ;

Sauter, B ;

Chowdhury, NR ;

Reddy, BVN ;

Thummala, NR ;

Droguett, G ;

Davidson, A ;

Ott, M ;

Horwitz, MS ;

Chowdhury, JR .

HEPATOLOGY, 1998, 27 (05) :1368-1376

[66] Recombinant Newcastle disease virus (NDV) with inserted gene coding for GM-CSF as a new vector for cancer immunogene therapy [J].

Janke, M. ;

Peeters, B. ;

de Leeuw, O. ;

Moorman, R. ;

Arnold, A. ;

Fournier, P. ;

Schirrmacher, V. .

GENE THERAPY, 2007, 14 (23) :1639-1649

[67] Activation of human T cells by a tumor vaccine infected with recombinant Newcastle disease virus producing IL-2 [J].

Janke, Markus ;

Peeters, Ben ;

Zhao, Heng ;

De Leeuw, Olav ;

Moorman, Rob ;

Arnold, Annette ;

Ziouta, Yvonne ;

Fournier, Philippe ;

Schirrmacher, Volker .

INTERNATIONAL JOURNAL OF ONCOLOGY, 2008, 33 (04) :823-832

[68] Sipuleucel-T Immunotherapy for Castration-Resistant Prostate Cancer. [J].

Kantoff, Philip W. ;

Higano, Celestia S. ;

Shore, Neal D. ;

Berger, E. Roy ;

Small, Eric J. ;

Penson, David F. ;

Redfern, Charles H. ;

Ferrari, Anna C. ;

Dreicer, Robert ;

Sims, Robert B. ;

Xu, Yi ;

Frohlich, Mark W. ;

Schellhammer, Paul F. ;

Ahmed, T. ;

Amin, A. ;

Arseneau, J. ;

Barth, N. ;

Bernstein, G. ;

Bracken, B. ;

Burch, P. ;

Caggiano, V. ;

Chin, J. ;

Chodak, G. ;

Chu, F. ;

Corman, J. ;

Curti, B. ;

Dawson, N. ;

Deeken, J. F. ;

Dubernet, T. ;

Fishman, M. ;

Flanigan, R. ;

Gailani, F. ;

Garbo, L. ;

Gardner, T. ;

Gelmann, E. ;

George, D. ;

Godfrey, T. ;

Gomella, L. ;

Guerra, M. ;

Hall, S. ;

Hanson, J. ;

Israeli, R. ;

Jancis, E. ;

Jewett, M. A. S. ;

Kassabian, V. ;

Katz, J. ;

Klotz, L. ;

Koeneman, K. ;

Koh, H. ;

Kratzke, R. .

NEW ENGLAND JOURNAL OF MEDICINE, 2010, 363 (05) :411-422

[69] Antitumor vaccination in patients with head and neck squamous cell carcinomas with autologous virus-modified tumor cells [J].

Karcher, J ;

Dyckhoff, G ;

Beckhove, P ;

Reisser, C ;

Brysch, M ;

Ziouta, Y ;

Helmke, BH ;

Weidauer, H ;

Schirrmacher, V ;

Herold-Mende, C .

CANCER RESEARCH, 2004, 64 (21) :8057-8061

[70] History of oncolytic viruses: Genesis to genetic engineering [J].

Kelly, Elizabeth ;

Russell, Stephen J. .

MOLECULAR THERAPY, 2007, 15 (04) :651-659

← 2 3 4 5 6 7 8 9 10 11 →