APPLICATIONS OF NEXT-GENERATION SEQUENCING The human microbiome: at the interface of health and disease

被引：2324

作者：

Cho, Ilseung ^{[1
,2
]}

Blaser, Martin J. ^{[1
,2
,3
,4
]}

机构：

[1] NYU, Dept Med, Langone Med Ctr, New York, NY 10016 USA

[2] Vet Affairs Med Ctr Manhattan, New York Harbor Dept, New York, NY 10010 USA

[3] NYU, Dept Microbiol, Langone Med Ctr, New York, NY 10016 USA

[4] NYU, Dept Biol, New York, NY 10003 USA

来源：

NATURE REVIEWS GENETICS | 2012年 / 13卷 / 04期

关键词：

HUMAN GUT MICROBIOTA; HELICOBACTER-PYLORI; CROHNS-DISEASE; BACTERIAL MICROBIOTA; COMMENSAL BACTERIA; BODY HABITATS; DELIVERY MODE; OBESITY; ASSOCIATION; COMMUNITY;

D O I：

10.1038/nrg3182

中图分类号：

Q3 [遗传学];

学科分类号：

071007 ; 090102 ;

摘要：

Interest in the role of the microbiome in human health has burgeoned over the past decade with the advent of new technologies for interrogating complex microbial communities. The large- scale dynamics of the microbiome can be described by many of the tools and observations used in the study of population ecology. Deciphering the metagenome and its aggregate genetic information can also be used to understand the functional properties of the microbial community. Both the microbiome and metagenome probably have important functions in health and disease; their exploration is a frontier in human genetics.

引用

页码：260 / 270

页数：11

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