Unlicensed and off label drug use in neonates

被引：210

作者：

Conroy, S ^{[1
]}

McIntyre, J ^{[1
]}

Choonara, I ^{[1
]}

机构：

[1] Univ Nottingham, Derbyshire Childrens Hosp, Acad Div Child Hlth, Derby DE22 3NE, England

来源：

ARCHIVES OF DISEASE IN CHILDHOOD-FETAL AND NEONATAL EDITION | 1999年 / 80卷 / 02期

关键词：

unlicensed off label drug use; intensive care;

D O I：

10.1136/fn.80.2.F142

中图分类号：

R72 [儿科学];

学科分类号：

100202 ;

摘要：

Aim-To determine the extent of use of drugs that are either not licensed (unlicensed), or are outside the terms of their product licence (off label) in a neonatal intensive care unit. Methods-A prospective study was conducted over 13 weeks. Results-455 prescription episodes were administered to 70 babies. 63 (90%) patients were given a drug that was either unlicensed or used in an off label way. 54.7% prescription episodes were off label, many for more than one reason, and 9.9% (45) were unlicensed; 35.4% (161) prescription episodes were licensed. Conclusion-The use of unlicensed and off label drugs in neonatal intensive care seems to be far greater than other paediatric settings. This highlights the difficulties faced by those trying to ensure safe and effective prescribing for neonates. Urgent action is required to resolve this situation.

引用

页码：F142 / F144

页数：3

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