Characterisation of the cellular uptake, of 5-aminolevulinic acid.

被引：4

作者：

Rud, E ^{[1
]}

Berg, K ^{[1
]}

机构：

[1] Norwegian Radium Hosp, Inst Canc Res, Dept Biophys, N-0310 Oslo, Norway

来源：

PHOTOHEMOTHERAPY OF CANCER AND OTHER DISEASES, PROCEEDINGS | 1999年 / 3563卷

关键词：

5-aminolevulinic acid; photodynamic therapy; cellular uptake;

D O I：

10.1117/12.339116

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Photodynamic therapy with 5-aminolevulinic acid (5-ALA) is a promising alternative treatment for several types of cancer. This work represents a first approach to characterise the transport system for 5-ALA in human cancer cells, using WiDr cells from a primary adenocarcinoma of the rectosigmoid colon as a model system. The transport of 5-ALA in WiDr was found to be dependent on pH and temperature, and partially inhibited by inhibitors of the energetic metabolism. Although WiDr was shown to express System A, a common transport system for small aliphatic amino acids, the transport of 5-ALA in WiDr was not found to be mediated by this system.

引用

页码：28 / 37

页数：10

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