Studies towards the total synthesis of Phostriecin

被引：6
|
作者：
Kumar, Gavireddy Chaithanya [1 ]
Muralikrishna, Katta [1 ]
Satyanarayana, Vavilapalli [1 ]
Kumar, Chintakrinda Suresh [1 ]
Yadav, Jhillu Singh [1 ]
机构：
[1] Indian Inst Chem Technol, CSIR, Ctr Semiochem Div, Hyderabad 500007, Andhra Prades, India
来源：
TETRAHEDRON LETTERS | 2018年 / 59卷 / 05期
关键词：
Wittig reaction; Alkoxyallylboration; Homoallylic alcohol; Ring-closing metathesis; Antitumor natural products; PROTEIN PHOSPHATASES; METATHESIS; ANALOGS; RUCL2(=CHR)(PR(3))(2); ASSIGNMENT; SULTRIECIN; REDUCTION; KETONES;
D O I：
10.1016/j.tetlet.2017.12.068
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
A synthetic approach toward the phostriecin, an antitumor natural product is, described. The key features of the present synthesis are Wittig reaction, synthesis of homoallylic alcohol using Brown's protocol (alkoxyallylboration) and RCM for the creation of unsaturated lactone moiety of phostriecin. (C) 2017 Published by Elsevier Ltd.
引用
收藏
页码：454 / 456
页数：3
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