CaMKII: New tricks for an old dog

被引:8
|
作者
Griffith, Leslie C. [1 ,2 ]
机构
[1] Brandeis Univ, Volen Ctr Complex Syst, Dept Biol, Waltham, MA 02454 USA
[2] Brandeis Univ, Natl Ctr Behav Genom, Waltham, MA 02454 USA
关键词
D O I
10.1016/j.cell.2008.04.018
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
Calcium/calmodulin-dependent protein kinase II (CaMKII) is a pivotal signaling molecule in both the brain and the heart. In this issue of Cell, Erickson et al. (2008) demonstrate a mechanism for CaMKII activation by reactive oxygen species that provides a direct link between kinase activation and cardiac dysfunction.
引用
收藏
页码:397 / 399
页数:4
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