Orally active amino functionalized antimalarial 1,2,4-trioxanes

被引：63

作者：

Singh, C ^{[1
]}

Malik, H

Puri, SK

机构：

[1] Cent Drug Res Inst, Div Med Chem, Lucknow 226001, Uttar Pradesh, India

[2] Cent Drug Res Inst, Div Parasitol, Lucknow 226001, Uttar Pradesh, India

来源：

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 2004年 / 14卷 / 02期

关键词：

D O I：

10.1016/j.bmcl.2003.10.051

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

Using readily available trioxanes 6a-b, a new series of amino functionalized 1,2,4-trioxanes 8a-e and 9a-e have been prepared and evaluated for antimalarial activity against multi-drug resistant Plasmodium yoelii in Swiss mice model. Several of these novel trioxanes are orally more active than the parent trioxanes 6a-b. Antimalarial activity of amino functionalized trioxane 9a, the most potent compound in the series, is very close to that of beta-arteether. (C) 2003 Elsevier Ltd. All rights reserved.

引用

页码：459 / 462

页数：4

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