Microfluidic Dual Emitter Electrospray Ionization Source for Accurate Mass Measurements

被引：37

作者：

Chambers, Andrew G. ^{[1
]}

Ramsey, J. Michael ^{[1
]}

机构：

[1] Univ N Carolina, Dept Chem, Chapel Hill, NC 27599 USA

来源：

ANALYTICAL CHEMISTRY | 2012年 / 84卷 / 03期

关键词：

ION-CYCLOTRON RESONANCE; LIQUID CHROMATOGRAPHY/MASS SPECTROMETRY; CAPILLARY-ELECTROPHORESIS; ION/ION REACTIONS; TRANSFER DISSOCIATION; INTERNAL CALIBRATION; REFERENCE SPRAYS; SEPARATE SAMPLE; TRAP; IMPLEMENTATION;

D O I：

10.1021/ac202603s

中图分类号：

O65 [分析化学];

学科分类号：

070302 ; 081704 ;

摘要：

A glass microfluidic device with two independent electrospray ionization (ESI) emitters has been designed to sequentially generate ions from different solutions for mass analysis. Rapid modulation between the emitters is accomplished by turning on and off the voltage that simultaneously generates the fluid flow rate and ESI potential. The time required to switch between the two electrospray signals is less than 70 ms. Using the second emitter to introduce a reference compound for internal calibration, accurate mass measurements (less than 3 ppm mass error) were obtained with a time-of-flight mass spectrometer.

引用

页码：1446 / 1451

页数：6

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