Is rheumatoid arthritis a risk factor for oral bisphosphonate-induced osteonecrosis of the jaws?

被引：20
作者：
Neto, Nicolau Conte [1 ]
Bastos, Alliny de Souza [1 ]
Chierici-Marcantonio, Rosemary Adriana [1 ]
Marcantonio, Elcio, Jr. [1 ]
机构：
[1] UNESP Univ Estadual Paulista, Araraquara Dent Sch, Dept Periodontol, Sao Paulo, Brazil
来源：
MEDICAL HYPOTHESES | 2011年 / 77卷 / 05期
关键词：
ACUTE-PHASE RESPONSE; OXIDATIVE STRESS; BONE TURNOVER; INDUCED APOPTOSIS; FOLIC-ACID; INHIBITION; METHOTREXATE; INVOLVEMENT; PREVALENCE; INFECTION;
D O I：
10.1016/j.mehy.2011.08.008
中图分类号：
R-3 [医学研究方法]; R3 [基础医学];
学科分类号：
1001 ;
摘要：
Bisphosphonate-related osteonecrosis of the jaws is a relevant side-effect of these drugs that has been generating a great concern through increasing reports, worldwide, of this bone necrosis. Among several BRONJ hypothetical co-factors that could play a role in BRONJ pathogenesis, rheumatoid arthritis (RA) has been included as a relevant risk factor for BRONJ; however, until now the relationship between these diseases has not been fully explained. Thus, the purpose of this paper is to establish hypothetical factors that could link these two diseases, considering mainly inflammatory components and the organism effects of medicines used to treat RA, particularly steroids and methotrexate (MTX). (C) 2011 Elsevier Ltd. All rights reserved.
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收藏
页码：905 / 911
页数：7
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