Expression of resistance-related proteins in tumoral and peritumoral tissues of patients with lung cancer

被引：30
作者：
Koomagi, R
Stammler, G
Manegold, C
Mattern, J
Volm, M
机构：
[1] GERMAN CANC RES CTR, DEPT ONCOL DIAG & THERAPY, D-69120 HEIDELBERG, GERMANY
[2] THORAX CLIN HEIDELBERG ROHRBACH, D-69126 HEIDELBERG, GERMANY
来源：
CANCER LETTERS | 1996年 / 110卷 / 1-2期
关键词：
resistance; lung tumors; normal tissue; P-glycoprotein; glutathione S-transferase; metallothionein; topoisomerase II; heat shock protein; proto-oncogenes; immunohistochemistry; smoking;
D O I：
10.1016/S0304-3835(96)04471-0
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
Twenty tumoral and peritumoral tissues from patients with lung cancer were analyzed immunohistochemically for the drug resistance-related proteins P-glycoprotein (P-170), topoisomerase II (Topo-II), glutathione S-transferase-pi (GST-pi), metallothionein (MT), heat shock protein-70 (HSP-70) and the putative regulators of resistance (ErbB1, Fos and Jun). Protein expression of Topo-II, GST-pi, MT, HSP-70, ErbB1, Fos and Jun was elevated in tumor tissue in comparison to normal tissue. The different expression of the proteins between tumoral and normal tissues was statistically significant for Topo-II (P = 0.05), MT (P = 0.03), and HSP-70 (P = 0.01), whereas ErbB1 showed a borderline significance. The expression of the proteins was frequently increased in smokers in comparison to non-smokers. In general, the increase of the proteins of smokers corresponded in tumoral and non-tumoral tissue. Different expression was only found with MT and HSP-70 which were higher in tissues of smokers.
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收藏
页码：129 / 136
页数：8
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