A simple in vivo atrial fibrillation model of rat induced by transesophageal atrial burst pacing

被引：13

作者：

Sugiyama, A ^{[1
]}

Takahara, A ^{[1
]}

Honsho, S ^{[1
]}

Nakamura, Y ^{[1
]}

Hashimoto, K ^{[1
]}

机构：

[1] Univ Yamanashi, Interdisciplinary Grad Sch Med & Engn, Dept Pharmacol, Tamaho, Yamanashi 4093898, Japan

来源：

JOURNAL OF PHARMACOLOGICAL SCIENCES | 2005年 / 98卷 / 03期

关键词：

atrial fibrillation; pilsicainide; pentobarbital;

D O I：

10.1254/jphs.SCJ05002X

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

A simple in vivo closed-chest atrial fibrillation (Af) model of rats was developed. Af was reproducibly induced by transesophageal atrial burst pacing for 30 s in each of the pento-barbital-anesthetized rats, whereas the cardiohemodynamic condition as well as the inducibility and duration of Af episode was stable over time. Moreover, the anti-Af effect of the class Ic drug pilsicainide was confirmed in this model, which was essentially the same as those reported previously in other Af animal models and clinical practice. Thus, this new model may become an alternative to current techniques.

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收藏

页码：315 / 318

页数：4

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