Isoliquiritigenin Attenuates Anxiety-Like Behavior and Locomotor Sensitization in Rats after Repeated Exposure to Nicotine

被引:6
作者
Wang, Yuhua [1 ]
Kim, Sang Chan [2 ]
Wu, Tong [1 ]
Jiao, Yu [1 ]
Jin, Haifeng [1 ]
Lee, Bong Hyo [2 ]
Lee, Chul Won [2 ]
Fan, Yu [2 ]
Kim, Hee Young [2 ]
Yang, Chae Ha [2 ]
Zhao, Zhenglin [3 ]
Zhao, Rongjie [1 ,2 ]
机构
[1] Qiqihar Med Univ, Dept Psychopharmacol, Qiqihar 161006, Peoples R China
[2] Daegu Haany Univ, Coll Oriental Med, Med Res Ctr, Daegu 706060, South Korea
[3] Qiqihar Med Univ, Dept Biochem, Qiqihar 161006, Peoples R China
基金
新加坡国家研究基金会;
关键词
EXTRACELLULAR DOPAMINE RELEASE; GLYCYRRHIZAE-RADIX; NUCLEUS-ACCUMBENS; WITHDRAWAL; COCAINE; EXPRESSION; NEUROTOXICITY; INVOLVEMENT; SUPPRESSES; MODULATION;
D O I
10.1155/2020/9692321
中图分类号
R [医药、卫生];
学科分类号
10 ;
摘要
As important components of positive and negative reinforcement, locomotor sensitization and withdrawal anxiety following repeated exposure to nicotine (NIC) constitute crucial risk factors for relapse to NIC use after abstinence. Glycyrrhiza radix (G. radix), an important tonic used in traditional Oriental medicine, has not only anxiolytic effects but also reduces NIC-induced locomotor sensitization. Isoliquiritigenin (ISL), a bioactive ingredient of G. radix, also exhibits neuropharmacological effects, including anxiolytic action. Previously, we reported that ISL suppressed cocaine-induced extracellular dopamine release in the nucleus accumbens shell (NaccSh) and attenuated methamphetamine-induced neurotoxicity. The present study was performed to evaluate the effects of ISL on both NIC withdrawal anxiety and locomotor sensitization. Adult male rats received subcutaneous administration of NIC hydrogen tartrate (0.4 mg/kg, twice a day) for 7 days followed by 4 days of withdrawal. During the period of NIC withdrawal, the rats received four intragastric treatments with ISL (3, 10, or 30 mg/kg/day). All three doses of ISL significantly inhibited NIC withdrawal-induced anxiety-like behaviors in the elevated plus maze (EPM) test, but only the 10 mg/kg/day and 30 mg/kg/day ISL doses attenuated locomotor sensitization induced by a challenge dose of NIC. Intracerebroventricular ISL also inhibited both NIC-induced withdrawal anxiety and locomotor sensitization, but intra-NaccSh injection of ISL blocked only NIC locomotor sensitization, which was abolished by post-ISL infusion of tert-butyl hydroperoxide (an oxidant) or N-methyl-d-aspartate (NMDA) into the NaccSh. Moreover, there was increased protein expression of phosphorylated Erk1/2 in the NIC-sensitized NaccSh, which was suppressed by ISL. Taken together, these results suggest that ISL can inhibit repeated NIC-induced withdrawal anxiety and locomotor sensitization, and the latter is mediated by antagonizing accumbal reactive oxygen species and NMDA receptor signaling.
引用
收藏
页数:14
相关论文
共 50 条
  • [1] Review of pharmacological effects of Glycyrrhiza sp and its bioactive compounds
    Asl, Marjan Nassiri
    Hosseinzadeh, Hossein
    [J]. PHYTOTHERAPY RESEARCH, 2008, 22 (06) : 709 - 724
  • [2] Balfour DJK, 2015, CURR TOP BEHAV NEURO, V24, P99, DOI 10.1007/978-3-319-13482-6_4
  • [3] Neurobiology of nicotine addiction: Implications for smoking cessation treatment
    Benowitz, Neal L.
    [J]. AMERICAN JOURNAL OF MEDICINE, 2008, 121 (04) : S3 - S10
  • [4] Neuropeptide systems and new treatments for nicotine addiction
    Bruijnzeel, Adriaan W.
    [J]. PSYCHOPHARMACOLOGY, 2017, 234 (9-10) : 1419 - 1437
  • [5] Activation of AMPK by metformin improves withdrawal signs precipitated by nicotine withdrawal
    Brynildsen, Julia K.
    Lee, Bridgin G.
    Perron, Isaac J.
    Jin, Sunghee
    Kim, Sangwon F.
    Blendy, Julie A.
    [J]. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2018, 115 (16) : 4282 - 4287
  • [6] Role of dopamine in the behavioural actions of nicotine related to addiction
    Di Chiara, G
    [J]. EUROPEAN JOURNAL OF PHARMACOLOGY, 2000, 393 (1-3) : 295 - 314
  • [7] Nicotinic receptor-based therapeutics and candidates for smoking cessation
    Dwoskin, Linda P.
    Smith, Andrew M.
    Wooters, Thomas E.
    Zhang, Zhenfa
    Crooks, Peter A.
    Bardo, Michael T.
    [J]. BIOCHEMICAL PHARMACOLOGY, 2009, 78 (07) : 732 - 743
  • [8] Eberhart L., 2014, Abstracts of the General Meeting of the American Society for Microbiology, V114, P881
  • [9] Aqueous Extract of Semen Ziziphi Spinosae Exerts Anxiolytic Effects during Nicotine Withdrawal via Improvement of Amygdaloid CRF/CRF1R Signaling
    Gu, Changhong
    Zhao, ZhengLin
    Zhu, Xiaodong
    Wu, Tong
    Lee, Bong Hyo
    Jiao, Yu
    Lee, Chul Won
    Jung, Dae Hwa
    Yang, Chae Ha
    Zhao, Rongjie
    Kim, Sang Chan
    [J]. EVIDENCE-BASED COMPLEMENTARY AND ALTERNATIVE MEDICINE, 2018, 2018
  • [10] Biotransformation of the chemopreventive agent 2′,4′,4-trihydroxychalcone (isoliquiritigenin) by UDP-glucuronosyltransferases
    Guo, Jian
    Liu, Ang
    Cao, Hongmei
    Luo, Yan
    Pezzuto, John M.
    van Breemen, Richard B.
    [J]. DRUG METABOLISM AND DISPOSITION, 2008, 36 (10) : 2104 - 2112