Non-Targeted Dried Blood Spot-Based Metabolomics Analysis Showed Rice Bran Supplementation Effects Multiple Metabolic Pathways during Infant Weaning and Growth in Mali

被引：5

作者：

Pfluger, Brigitte A. ^{[1
]}

Smith, Hillary V. ^{[2
]}

Weber, Annika M. ^{[3
,4
]}

Ibrahim, Hend ^{[4
,5
]}

Doumbia, Lassina ^{[6
]}

Bore, Abdoulaye ^{[6
]}

Cissoko, Alima ^{[6
]}

Douyon, Seydou ^{[6
]}

Kone, Karim ^{[6
]}

Sangare, Lansana ^{[6
]}

Maiga, Ababacar ^{[6
]}

Koita, Ousmane A. ^{[6
]}

Goodman, Kelli ^{[7
]}

Evans, Anne M. ^{[7
]}

Ryan, Elizabeth P. ^{[2
,4
]}

机构：

[1] Emory Univ, Laney Grad Sch, Nutr & Hlth Sci, Atlanta, GA 30322 USA

[2] Colorado State Univ, Colorado Sch Publ Hlth, Dept Global Hlth & Hlth Dispar, Ft Collins, CO 80523 USA

[3] Colorado State Univ, Dept Food Sci & Human Nutr, Ft Collins, CO 80523 USA

[4] Colorado State Univ, Dept Environm & Radiol Hlth Sci, Ft Collins, CO 80523 USA

[5] Zagazig Univ, Fac Med, Dept Med Biochem, Zagazig 44519, Egypt

[6] Univ Sci Tech & Technol Bamako, Lab Appl Biol, Fac Sci & Technol, E-3206 Bamako, Mali

[7] Metabolon Inc, Morrisville, NC 27560 USA

来源：

NUTRIENTS | 2022年 / 14卷 / 03期

关键词：

rice bran; dried blood spots; metabolomics; nutrition; complementary feeding; Mali; EARLY-CHILDHOOD; PATTERNS; CHOLINE; HEALTH; ZINC;

D O I：

10.3390/nu14030609

中图分类号：

R15 [营养卫生、食品卫生]; TS201 [基础科学];

学科分类号：

100403 ;

摘要：

Rice bran contains essential nutrients, antioxidants, and bioactives with anti-inflammatory and diarrheal protective properties important for infants. This 6-month randomized controlled trial investigated the effects of heat-stabilized rice bran supplementation during Malian infant weaning. Fifty healthy 6-month-old infants were randomized to a rice bran intervention (N = 25) or non-intervention control group (N = 25). Intervention infants received dose-escalating rice bran supplementation for 6 months (1-5 g/day). Monthly infant dried blood spot and anthropometric measurements were collected. Dried blood spot metabolite abundances were compared monthly according to diet for six months. Supplementation resulted in favorable weight-for-age and weight-for-length z-score changes. Non-targeted dried blood spot-based metabolomics identified 796 metabolites, of which 33% had significant fold differences between groups (7-12 months). Lipids and amino acids represented 70.6% of the metabolites identified. Rice bran supplementation during infant weaning significantly modulated the metabolites involved in antioxidant defenses and with neuroactive properties including reduced glutathione, glycine, glutamate, cysteinylglycine, tryptophan betaine, and choline. These findings support rice bran as a weaning ingredient to meet infant nutritional requirements and with the potential to reduce oxidative stress and improve cognitive outcomes. This study provides evidence for dried blood spots as a cost-effective tool to detect infant biomarkers of nutritional and metabolic status.

引用

页数：20