Allergy in Evolution

被引:0
作者
Platts-Mills, Thomas A. E. [1 ]
机构
[1] Univ Virginia, Asthma & Allergy Dis Ctr, Charlottesville, VA 22908 USA
来源
NEW TRENDS IN ALLERGY AND ATOPIC ECZEMA | 2012年 / 96卷
关键词
ASTHMA; CHILDREN; ANTIBODIES; GALACTOSE-ALPHA-1,3-GALACTOSE; SENSITIZATION; RELEVANCE; PROTEINS; DISEASE; TRENDS; ATOPY;
D O I
暂无
中图分类号
R392 [医学免疫学];
学科分类号
100102 ;
摘要
The 'foreignness' of proteins that we encounter in our homes and outdoors is in large part dependent on their evolutionary distance from man. This is relevant to understanding the differences between mammalian allergens, e.g. cats, and arthropod allergens, e.g. mites and cockroaches, as well as to understanding responses to a wide range of food allergens. On the other hand, allergic disease has gone through a major evolution of its own from a prehygiene state where there is minimal production of allergen-specific IgE, to the production of high-titer IgE, and then to the dramatic increase in asthma. The challenge is to understand how changes in both hygiene and lifestyle have contributed to the changes in allergic disease. Copyright (C) 2012 S. Karger AG, Basel
引用
收藏
页码:1 / 6
页数:6
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