Insights into human endometrial receptivity from transcriptomic and proteomic data

被引：84
作者：
Haouzi, Delphine [1 ,2 ,3 ]
Dechaud, Herve [1 ,2 ,3 ]
Assou, Said [1 ,2 ,3 ]
De Vos, John [1 ,3 ]
Hamamah, Samir [1 ,2 ,3 ]
机构：
[1] Hop St Eloi, INSERM U847, Inst Rech Biotherapie, CHU Montpellier, F-34295 Montpellier 5, France
[2] Hop Arnaud de Villeneuve, Dept Med & Biol Reprod, ART PGD Div, CHU Montpellier, F-34295 Montpellier 5, France
[3] Univ Montpellier I, UFR Med, Lab Dev Embryonnaire Precoce & Cellules Souches E, F-34000 Montpellier, France
来源：
REPRODUCTIVE BIOMEDICINE ONLINE | 2012年 / 24卷 / 01期
关键词：
biomarkers; endometrial receptivity; IVF; omics; stimulated cycles; HUMAN CHORIONIC-GONADOTROPIN; CONTROLLED OVARIAN HYPERSTIMULATION; GENE-EXPRESSION PROFILES; IN-VITRO FERTILIZATION; GNRH ANTAGONIST; STIMULATED CYCLES; EMBRYONIC IMPLANTATION; UTERINE RECEPTIVITY; MONOAMINE-OXIDASE; MENSTRUAL-CYCLE;
D O I：
10.1016/j.rbmo.2011.09.009
中图分类号：
R71 [妇产科学];
学科分类号：
100211 ;
摘要：
The appreciation of endometrial receptivity is a crucial step in assisted reproductive technology as implantation failures are thought to result, in large part, from abnormal endometrial receptivity. Using emerging omics technologies, investigators have begun to define both molecular signatures and specific biomarkers of receptive endometrium. The aim of this review was to analyse the new perspectives brought to the appreciation of endometrial receptivity by transcriptomic and proteomic technologies, involving the analysis of gene-or protein-expression-profile shifts between the pre-receptive and receptive secretory stages and how they might lead to new strategies for endometrial receptivity assessments. The use of omics as molecular tools to determine the effects of stimulation protocols on endometrial gene expression and clinical outcomes has also been investigated. (C) 2011, Reproductive Healthcare Ltd. Published by Elsevier Ltd. All rights reserved.
引用
收藏
页码：23 / 34
页数：12
相关论文
共 92 条
[1]   Uterine receptivity to human embryonic implantation: Histology, biomarkers, and transcriptomics [J].
Aghajanova, L. ;
Hamilton, A. E. ;
Giudice, L. C. .
SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY, 2008, 19 (02) :204-211
[2]  
Al-Inany H.G., 2006, COCHRANE DB SYST REV, V3, DOI DOI 10.1002/14651858.CD001750.PUB2
[3]   Is there a uniform basal endometrial gene expression profile during the implantation window in women who became pregnant in a subsequent ICSI cycle? [J].
Allegra, A. ;
Marino, A. ;
Coffaro, F. ;
Lama, A. ;
Rizza, G. ;
Scaglione, P. ;
Sammartano, F. ;
Santoro, A. ;
Volpes, A. .
HUMAN REPRODUCTION, 2009, 24 (10) :2549-2557
[4]  
Aplin J D, 2007, Reprod Biomed Online, V14 Spec No 1, P49, DOI 10.1016/S1472-6483(10)61458-7
[5]   ENDOMETRIAL MORPHOLOGY AND HORMONAL PROFILES IN INVITRO FERTILIZATION PATIENTS [J].
BARASH, A ;
CZERNOBILSKY, B ;
INSLER, V ;
BORENSTEIN, R ;
ROSENBERG, M ;
FINK, A .
EUROPEAN JOURNAL OF OBSTETRICS GYNECOLOGY AND REPRODUCTIVE BIOLOGY, 1992, 44 (02) :117-121
[6]   Local injury to the endometrium doubles the incidence of successful pregnancies in patients undergoing in vitro fertilization [J].
Barash, A ;
Dekel, N ;
Fieldust, S ;
Segal, I ;
Schechtman, E ;
Granot, I .
FERTILITY AND STERILITY, 2003, 79 (06) :1317-1322
[7]   Morphometric analysis of peri-implantation endometrium in patients having excessively high oestradiol concentrations after ovarian stimulation [J].
Basir, GS ;
O, WS ;
Ng, EHY ;
Ho, PC .
HUMAN REPRODUCTION, 2001, 16 (03) :435-440
[8]   STATUS OF HCG/LH RECEPTOR AND G-PROTEINS IN HUMAN ENDOMETRIUM DURING ARTIFICIAL CYCLES OF HORMONE REPLACEMENT THERAPY [J].
BERNARDINI, L ;
MORETTIROJAS, I ;
BRUSH, M ;
ROJAS, FJ ;
BALMACEDA, JP .
JOURNAL OF THE SOCIETY FOR GYNECOLOGIC INVESTIGATION, 1995, 2 (04) :630-635
[9]   Cytokine profiling in endometrial secretions: a non-invasive window on endometrial receptivity [J].
Boomsma, C. M. ;
Kavelaars, A. ;
Eijkemans, M. J. C. ;
Amarouchi, K. ;
Teklenburg, G. ;
Gutknecht, D. ;
Fauser, B. J. C. M. ;
Heijnen, C. J. ;
Macklon, N. S. .
REPRODUCTIVE BIOMEDICINE ONLINE, 2009, 18 (01) :85-94
[10]   Endometrial hormone receptors and proliferation index in the periovulatory phase of stimulated embryo transfer cycles in comparison with natural cycles and relation to clinical pregnancy outcome [J].
Bourgain, C ;
Ubaldi, F ;
Tavaniotou, A ;
Smitz, J ;
Van Steirteghem, AC ;
Devroey, P .
FERTILITY AND STERILITY, 2002, 78 (02) :237-244
12345678910