t(X;14)(p11.4;q32.33) is recurrent in marginal zone lymphoma and up-regulates GPR34

被引：31

作者：

Baens, Mathijs ^{[1
,2
]}

Ferreiro, Julio Finalet ^{[1
]}

Tousseyn, Thomas ^{[3
]}

Urbankova, Helena ^{[1
]}

Michaux, Lucienne ^{[1
]}

de Leval, Laurence ^{[6
]}

Dierickx, Daan ^{[4
]}

Wolter, Pascal ^{[5
]}

Sagaert, Xavier ^{[3
]}

Vandenberghe, Peter ^{[1
]}

De Wolf-Peeters, Christiane ^{[3
]}

Wlodarska, Iwona ^{[1
]}

机构：

[1] Katholieke Univ Leuven, Ctr Human Genet, B-3000 Louvain, Belgium

[2] Katholieke Univ Leuven VIB, Dept Mol & Dev Genet, Louvain, Belgium

[3] Katholieke Univ Leuven, Dept Pathol, B-3000 Louvain, Belgium

[4] Katholieke Univ Leuven, Dept Hematol, B-3000 Louvain, Belgium

[5] Katholieke Univ Leuven, Dept Gen Med Oncol, B-3000 Louvain, Belgium

[6] CHU Sart Tilman, Dept Pathol, B-4000 Liege, Belgium

来源：

HAEMATOLOGICA-THE HEMATOLOGY JOURNAL | 2012年 / 97卷 / 02期

关键词：

marginal zone lymphoma; mucosa-associated lymphoid tissue lymphoma; chromosomal translocation; IGH; GPR34; PROTEIN-COUPLED RECEPTORS; MALT LYMPHOMA; DISCOVERY; CANCER; CELLS;

D O I：

10.3324/haematol.2011.052639

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Genetic events underlying pathogenesis of nodal and extranodal marginal zone lymphoma are not completely understood. We report here a novel t(X;14)(p11.4;q32.33) identified in 4 lymphoma cases: 2 with a mucosa-associated lymphoid tissue lymphoma, one with a nodal marginal zone lymphoma and one with gastric diffuse large B-cell lymphoma. In all cases, lymphoma evolved from a previous auto-immune disorder. Fluorescence in situ hybridization and molecular studies showed that t(X; 14), which is mediated by immunoglobulin heavy chain locus, targets the GPR34 gene at Xp11.4. Upregulation of GPR34 mRNA and aberrant expression of GPR34 protein has been demonstrated in 3 presented cases by quantitative real-time polymerase chain reaction and immunohistochemistry, respectively. GPR34 belongs to the largest family of cell surface molecules involved in signal transmission that play important roles in many physiological and pathological processes, including tumorigenesis. Although functional consequences of t(X; 14) have not been identified, our studies suggest that up-regulated GPR34 activate neither nuclear factor-kappa B nor ELK-related tyrosine kinase.

引用

页码：184 / 188

页数：5

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