Physiological and pathological insights into exosomes in the brain

被引：24
作者：
Li, Xiao-Hui [1 ,3 ,7 ]
Zhang, Juan [1 ,3 ,7 ]
Li, Ding-Feng [1 ,3 ,6 ,7 ]
Wu, Wei [4 ]
Xie, Zhong-Wen [2 ]
Liu, Qiang [1 ,3 ,5 ,7 ]
机构：
[1] Univ Sci & Technol China, Hefei Natl Lab Phys Sci Microscale, Div Life Sci & Med, Sch Life Sci,Inst Aging & Brain Disorders,Affilil, Hefei 230001, Anhui, Peoples R China
[2] Anhui Agr Univ, State Key Lab Tea Plant Biol & Utilizat, Hefei 230036, Anhui, Peoples R China
[3] Univ Sci & Technol China, Neurodegenerat Dis Res Ctr, Hefei 230026, Anhui, Peoples R China
[4] Univ Sci & Technol China, Affiliated Hosp 1, Organ Transplantat Ctr, Hefei 230001, Anhui, Peoples R China
[5] Chinese Acad Sci, CAS Ctr Excellence Anim Evolut & Genet, Kunming 650223, Yunnan, Peoples R China
[6] Univ Sci & Technol China, Natl Synchrotron Radiat Lab, Hefei 230029, Anhui, Peoples R China
[7] Univ Sci & Technol China, CAS Key Lab Brain Funct & Dis, Hefei 230026, Anhui, Peoples R China
来源：
ZOOLOGICAL RESEARCH | 2020年 / 41卷 / 04期
基金：
中国国家自然科学基金; 中国博士后科学基金;
关键词：
Exosomes; Brain; Neurodegenerative diseases; Cell-cell communication; EXTRACELLULAR VESICLES; ALZHEIMERS-DISEASE; ALPHA-SYNUCLEIN; NEURITE OUTGROWTH; SECRETE EXOSOMES; AMYLOID-BETA; PROTEINS; CELL; ASTROCYTES; RELEASE;
D O I：
10.24272/j.issn.2095-8137.2020.043
中图分类号：
Q95 [动物学];
学科分类号：
071002 ;
摘要：
Exosomes are small vesicles secreted by all cell types in the brain and play a role in cell-cell communication through the transfer of cargo or encapsulation. Exosomes in the brain have considerable impact on neuronal development, activation, and regeneration. In addition, exosomes are reported to be involved in the onset and propagation of various neurodegenerative diseases. In this review, we discuss the content of exosomes derived from major cell types in the brain, and their function under physiological and pathological conditions.
引用
收藏
页码：365 / 372
页数：8
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