Induction of apoptosis by Rhizoma Paridis saponins in MCF-7 human breast cancer cells

被引：0
|
作者：
Lu, Chuan [1 ]
Li, ChunJiang [1 ,2 ]
Wu, Dongmei [1 ]
Lu, JingMei [1 ]
Tu, Fan [1 ]
Wang, Lijuan [3 ]
机构：
[1] NE Normal Univ, Sch Life Sci, Changchun 130024, Jilin Province, Peoples R China
[2] Jiamusi Univ, Coll Basic Med, Jiamusi 154007, Heilongjiang Pr, Peoples R China
[3] Hosp Eye, Dept Ophthalmol, Harbin 150001, Heilongjiang Pr, Peoples R China
来源：
AFRICAN JOURNAL OF PHARMACY AND PHARMACOLOGY | 2011年 / 5卷 / 08期
关键词：
Rhizoma paridis saponins; MCF-7; cells; apoptosis; mitochondria; POLYPHYLLIN-D; PROTEINS; DEATH;
D O I：
暂无
中图分类号：
R9 [药学];
学科分类号：
1007 ;
摘要：
This study investigates the relationship between the induction of MCF-7 human breast cancer cell apoptosis by Rhizoma Paridis saponins (RPS) and the mitochondrial apoptotic pathway. We treated MCF-7 cells with RPS at various concentrations and examined the inhibitory effect of RPS on the proliferation of MCF-7 cells using the 4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) assay, the change in mitochondrial membrane potential (MMP) using JC-1 staining, and the expression levels of related proteins using western blot. The results showed that the inhibitory effect of RPS against the growth of MCF-7 human breast cancer cells might be related to the apoptosis induced caspase family and the caspase-3-dependent pathway. The results suggest that RPS has the potential to be a valuable anticancer agent.
引用
收藏
页码：1086 / 1091
页数：6
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