Vasculogenic Mimicry: Lessons from Melanocytic Tumors

被引：0

作者：

Spiliopoulos, Konstantinos ^{[1
]}

Peschos, Dimitrios ^{[2
]}

Batistatou, Anna ^{[3
]}

Ntountas, Ioannis ^{[4
]}

Agnantis, Niki ^{[2
]}

Kitsos, Georgios ^{[1
]}

机构：

[1] Univ Hosp Ioannina, Dept Ophthalmol, Ioannina 45500, Greece

[2] Univ Hosp Ioannina, Dept Physiol, Ioannina 45500, Greece

[3] Univ Hosp Ioannina, Dept Pathol, Ioannina 45500, Greece

[4] Univ Athens, G Gennimatas Gen Hosp Athens, Dept Ophthalmol 1, Athens, Greece

来源：

IN VIVO | 2015年 / 29卷 / 03期

关键词：

Melanocytic; mimicry; tumor; vasculogenic; review; AGGRESSIVE MELANOMA PHENOTYPE; HUMAN UVEAL MELANOMA; CUTANEOUS MALIGNANT-MELANOMA; FLUID-CONDUCTING MESHWORK; ENDOTHELIAL GROWTH-FACTOR; LAMININ-5; GAMMA-2; CHAIN; CHANNEL FORMATION; VE-CADHERIN; EMBRYONIC VASCULOGENESIS; MOLECULAR REGULATION;

D O I：

暂无

中图分类号：

R-3 [医学研究方法]; R3 [基础医学];

学科分类号：

1001 ;

摘要：

Tumor cell vasculogenic mimicry refers to the formation of tumor cell-lined vessels that contribute to tumor neovascularization and nutrient and oxygen supply. These tumor cells express many endothelial and stem cell markers, resulting in them having a unique phenotype. This phenomenon is observed in a variety of neoplasms, such as glioblastomas and sarcomas, as well as breast, ovarian, liver and lung carcinomas. It is also evident in melanocytic lesions, regardless of their benign or malignant nature. The biochemical and molecular events that regulate vasculogenic mimicry provide opportunities for development of novel forms of tumor-targeted treatments. Furthermore, the presence of this process in a tumor might have prognostic implications.

引用

页码：309 / 317

页数：9

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