HapLogic: A Predictive Human Leukocyte Antigen-Matching Algorithm to Enhance Rapid Identification of the Optimal Unrelated Hematopoietic Stem Cell Sources for Transplantation

被引：55

作者：

Dehn, Jason ^{[1
]}

Setterholm, Michelle ^{[1
]}

Buck, Kelly ^{[1
]}

Kempenich, Jane ^{[1
]}

Beduhn, Beth ^{[1
]}

Gragert, Loren ^{[1
,2
]}

Madbouly, Abeer ^{[1
]}

Fingerson, Stephanie ^{[1
]}

Maiers, Martin ^{[1
]}

机构：

[1] Natl Marrow Donor Program, Minneapolis, MN USA

[2] Tulane Univ, Sch Med, Dept Pathol & Lab Med, Tulane Canc Ctr, 1430 Tulane Ave, New Orleans, LA 70112 USA

来源：

BIOLOGY OF BLOOD AND MARROW TRANSPLANTATION | 2016年 / 22卷 / 11期

关键词：

HLA matching; Predictive algorithm; Donor selection; Cord blood unit selection; CORD BLOOD TRANSPLANTATION; HLA ALLELES; DONOR; HLA-DPB1; MISMATCHES; VALIDATION; IMPACT; ASSOCIATIONS; RECOGNITION; VARIABILITY;

D O I：

10.1016/j.bbmt.2016.07.022

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

The search for a suitable human leukocyte antigen (HLA)-matched unrelated adult stem cell donor (URD) or umbilical cord blood unit (UCB) is a complex process. The National Marrow Donor Program (NMDP) developed a search algorithm known as HapLogic, which is currently provided within the NMDP Traxis application. The HapLogic algorithm has been in use since 2006 and has advanced URD/UCB HLA-matching technology. The algorithm has been shown to have high predictive accuracy, which can streamline URD/UCB selection and drive efficiencies in the search process to the benefit of the stem cell transplantation community. Here, we describe the fundamental components of the NMDP matching algorithm, output, validation, and future directions. (C) 2016 American Society for Blood and Marrow Transplantation.

引用

页码：2038 / 2046

页数：9

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