HapLogic: A Predictive Human Leukocyte Antigen-Matching Algorithm to Enhance Rapid Identification of the Optimal Unrelated Hematopoietic Stem Cell Sources for Transplantation

被引：54
作者：
Dehn, Jason [1 ]
Setterholm, Michelle [1 ]
Buck, Kelly [1 ]
Kempenich, Jane [1 ]
Beduhn, Beth [1 ]
Gragert, Loren [1 ,2 ]
Madbouly, Abeer [1 ]
Fingerson, Stephanie [1 ]
Maiers, Martin [1 ]
机构：
[1] Natl Marrow Donor Program, Minneapolis, MN USA
[2] Tulane Univ, Sch Med, Dept Pathol & Lab Med, Tulane Canc Ctr, 1430 Tulane Ave, New Orleans, LA 70112 USA
来源：
BIOLOGY OF BLOOD AND MARROW TRANSPLANTATION | 2016年 / 22卷 / 11期
关键词：
HLA matching; Predictive algorithm; Donor selection; Cord blood unit selection; CORD BLOOD TRANSPLANTATION; HLA ALLELES; DONOR; HLA-DPB1; MISMATCHES; VALIDATION; IMPACT; ASSOCIATIONS; RECOGNITION; VARIABILITY;
D O I：
10.1016/j.bbmt.2016.07.022
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
The search for a suitable human leukocyte antigen (HLA)-matched unrelated adult stem cell donor (URD) or umbilical cord blood unit (UCB) is a complex process. The National Marrow Donor Program (NMDP) developed a search algorithm known as HapLogic, which is currently provided within the NMDP Traxis application. The HapLogic algorithm has been in use since 2006 and has advanced URD/UCB HLA-matching technology. The algorithm has been shown to have high predictive accuracy, which can streamline URD/UCB selection and drive efficiencies in the search process to the benefit of the stem cell transplantation community. Here, we describe the fundamental components of the NMDP matching algorithm, output, validation, and future directions. (C) 2016 American Society for Blood and Marrow Transplantation.
引用
收藏
页码：2038 / 2046
页数：9
相关论文
共 40 条
  • [1] Back to the Future: Mismatched Unrelated Donor, Haploidentical Related Donor, or Unrelated Umbilical Cord Blood Transplantation?
    Anasetti, Claudio
    Aversa, Franco
    Brunstein, Claudio G.
    [J]. BIOLOGY OF BLOOD AND MARROW TRANSPLANTATION, 2012, 18 (01) : S161 - S165
  • [2] Aversa Franco, 2007, Curr Stem Cell Res Ther, V2, P105, DOI 10.2174/157488807779316973
  • [3] Lack of recognition of HLA class I mismatches outside α1/α2 domains by CD8+ alloreactive T lymphocytes: the HLA-B44 paradigm
    Bettens, F.
    Schanz, U.
    Tiercy, J-M
    [J]. TISSUE ANTIGENS, 2013, 81 (06): : 414 - 418
  • [4] A comparative reference study for the validation of HLA-matching algorithms in the search for allogeneic hematopoietic stem cell donors and cord blood units
    Bochtler, W.
    Gragert, L.
    Patel, Z. I.
    Robinson, J.
    Steiner, D.
    Hofmann, J. A.
    Pingel, J.
    Baouz, A.
    Melis, A.
    Schneider, J.
    Eberhard, H. -P.
    Oudshoorn, M.
    Marsh, S. G. E.
    Maiers, M.
    Mueller, C. R.
    [J]. HLA, 2016, 87 (06) : 439 - 448
  • [5] Donor selection for natural killer cell receptor genes leads to superior survival after unrelated transplantation for acute myelogenous leukemia
    Cooley, Sarah
    Weisdorf, Daniel J.
    Guethlein, Lisbeth A.
    Klein, John P.
    Wang, Tao
    Le, Chap T.
    Marsh, Steven G. E.
    Geraghty, Daniel
    Spellman, Stephen
    Haagenson, Michael D.
    Ladner, Martha
    Trachtenberg, Elizabeth
    Parham, Peter
    Miller, Jeffrey S.
    [J]. BLOOD, 2010, 116 (14) : 2411 - 2419
  • [6] The Impact of Amino Acid Variability on Alloreactivity Defines a Functional Distance Predictive of Permissive HLA-DPB1 Mismatches in Hematopoietic Stem Cell Transplantation
    Crivello, Pietro
    Zito, Laura
    Sizzano, Federico
    Zino, Elisabetta
    Maiers, Martin
    Mulder, Arend
    Toffalori, Cristina
    Naldini, Luigi
    Ciceri, Fabio
    Vago, Luca
    Fleischhauer, Katharina
    [J]. BIOLOGY OF BLOOD AND MARROW TRANSPLANTATION, 2015, 21 (02) : 233 - 241
  • [7] Effects of transmembrane region variability on cell surface expression and allorecognition of HLA-DP3
    Crivello, Pietro
    Lauterbach, Nina
    Zito, Laura
    Sizzano, Federico
    Toffalori, Cristina
    Marcon, Jessica
    Curci, Laura
    Mulder, Arend
    Wieten, Lotte
    Zino, Elisabetta
    Voorter, Christien E. M.
    Tilanus, Marcel G. J.
    Fleischhauer, Katharina
    [J]. HUMAN IMMUNOLOGY, 2013, 74 (08) : 970 - 977
  • [8] Using EasyMatch® to anticipate the identification of an HLA identical unrelated donor: A validated efficient time and cost saving method
    Dubois, Valerie
    Detrait, Marie
    Sobh, Mohamad
    Morisset, Stephan
    Labussiere, Helene
    Giannoli, Catherine
    Nicolini, Franck
    Moskovtchenko, Philippe
    Mialou, Valerie
    Ducastelle, Sophie
    Rey, Sylvie
    Thomas, Xavier
    Barraco, Fiorenza
    Tedone, Nathalie
    Marry, Evelyne
    Gamier, Federico
    Bertrand, Yves
    Michallet, Mauricette
    [J]. HUMAN IMMUNOLOGY, 2016, 77 (11) : 1008 - 1015
  • [9] Impact of allele-level HLA matching on outcomes after myeloablative single unit umbilical cord blood transplantation for hematologic malignancy
    Eapen, Mary
    Klein, John P.
    Ruggeri, Annalisa
    Spellman, Stephen
    Lee, Stephanie J.
    Anasetti, Claudio
    Arcese, William
    Barker, Juliet N.
    Baxter-Lowe, Lee Ann
    Brown, Maria
    Fernandez-Vina, Marcelo A.
    Freeman, John
    He, Wensheng
    Iori, Anna Paola
    Horowitz, Mary M.
    Locatelli, Franco
    Marino, Susana
    Maiers, Martin
    Michel, Gerard
    Sanz, Guillermo F.
    Gluckman, Eliane
    Rocha, Vanderson
    [J]. BLOOD, 2014, 123 (01) : 133 - 140
  • [10] Effect of donor-recipient HLA matching at HLA A, B, C, and DRB1 on outcomes after umbilical-cord blood transplantation for leukaemia and myelodysplastic syndrome: a retrospective analysis
    Eapen, Mary
    Klein, John P.
    Sanz, Guillermo F.
    Spellman, Stephen
    Ruggeri, Annalisa
    Anasetti, Claudio
    Brown, Maria
    Champlin, Richard E.
    Garcia-Lopez, Joan
    Hattersely, Gareth
    Koegler, Gesine
    Laughlin, Mary J.
    Michel, Gerard
    Nabhan, Samir K.
    Smith, Franklin O.
    Horowitz, Mary M.
    Gluckman, Eliane
    Rocha, Vanderson
    [J]. LANCET ONCOLOGY, 2011, 12 (13) : 1214 - 1221
1234